1an2_A : 3D-footprint complex

structure name	RECOGNITION BY MAX OF ITS COGNATE DNA THROUGH A DIMERIC B/HLH/Z DOMAIN (PROTEIN TRANSCRIPTION FACTOR MAX TF MAX)
reference	Nature 363 38 1993
source	Mus musculus
experiment	X-ray (resolution=2.90, R-factor=0.232)
structural superfamily	HLH, helix-loop-helix DNA-binding domain;
sequence family	Helixloophelix DNAbinding domain;
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 1an2_A interface=7,8,11,15, adkrahHNalErkrRdhikdsfhslrdsvpslqgekasraqildkateyiqymrrknhthqqdiddlkrqnalleqqvralekars
interface signature	HNER

Estimated binding specificities ?

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# IC=3.576 IC/col=0.894 n_of_columns=4

specificity:

A |   0   4   0  16
C |  96   4   0  16
G |   0  81   0  48
T |   0   7  96  16

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Related DNA sequences reported in the literature ?

site	source	matches (E-value)
term: MAX
CACGTG	PubMed	1an2_A(3.55e-04)
CACGCG	PubMed	1an2_A(3.55e-04)
GACCACGTGGTC	PubMed	1an2_A(7.15e-03)

Dendrogram of similar interfaces ?

matrix format

  
  ----HGNT--ET----RG--   L                              +1an2_A    
                                                 +------2 
  ----HGNTLGEC--RCRC--   L                       !      +5i50_B    
                                             +---3 
  --RT--NTRGEC--RCQT--                       !   !      +2ypa_A    
                                    +--------4   +------1 
  ------ST----AT--RTRG              !        !          +4zpk_B    
                             +------5        ! 
  KT--HGNT--EC--RCRG--   L   !      !        +----------1nkp_A    
                           --6      ! 
  ------NT--ET--RCMT--       !      +-------------------2ql2_D    
                             ! 
  ----HG----EC--RGRG--   L   +--------------------------4zpk_A

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updated Mon Dec 16 17:39:08 2024