1hlv_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF CENP-B(1-129) COMPLEXED WITH THE CENP-B BOX DNA (MAJOR CENTROMERE AUTOANTIGEN B)
reference	RIKEN Structural Genomics/Proteomics Initiative (RSGI)
source	HOMO SAPIENS
experiment	X-ray (resolution=2.50, R-factor=0.222)
structural superfamily	Homeodomain-like;
sequence family	CENPB Nterminal DNAbinding domain; Centromere binding protein B, DNA bind;
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 1hlv_A interface=5,7,39,40,41,43,44,68,70,119,120,124,125, mgpkRrQltfreksriiqeveenpdlrkgeiarrfnipPSTlSTilknkrailaserkygvastcrkTnKlspydkleglliawfqqiraaglpvkgiilkekalriaeelgmddftaSNgwlDRfrrrrs
interface signature	RQPSTSTTKSNDR

Estimated binding specificities ?

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# IC=13.437 IC/col=0.960 n_of_columns=14

specificity:

A |   3   0   3   0   0  24  10   5  11   3  96  78   0   0
C |   2  96  85  96   0  24   7   3  64  85   0   3  96   0
G |   3   0   5   0  96  24   8   0   7   3   0   1   0  96
T |  88   0   3   0   0  24  71  88  14   5   0  14   0   0

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Related DNA sequences reported in the literature ?

site	source	matches (E-value)
term: CENP-B
CTTCGTTGGAAACGGGA	PubMed	1hlv_A(1.11e-16)
CTTCGTTGGAAACGGGT	PubMed	1hlv_A(6.32e-13)
TCCCGTTTCCAACGAAG	PubMed	1hlv_A(1.11e-16)
TCCCGTTTCCA	PubMed	1hlv_A(1.87e-10)

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updated Sun Jun 28 03:37:29 2026