1hys_AB : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH A POLYPURINE TRACT RNA:DNA
reference	Sarafianos et al. 'EMBO 20 1449 2001
source	HUMAN IMMUNODEFICIENCY VIRUS 1
experiment	X-ray (resolution=3.00, R-factor=?)
structural superfamily	DNA/RNA polymerases;Ribonuclease H-like;
reference complex	7ozw_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 1hys_A interface=115,183,258,266,448,475, pispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdaYfsvpldedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdiviyqYmddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpivlpekdswtvndiQklvgklnWasqiypgikvrqlskllrgtkalteviplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyqlekepivgaetfyvdgaanRetklgkagyvtnkgrqkvvpltnttnQktelqaiylalqdsglevnivtdsqyalgiiqaqpdkseselvnqiieqlikkekvylawvpahkgiggneqvdklvs > 1hys_B interface= pispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdaYfsvpldedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdiviyqYmddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpivlpekdswtvndiQklvgklnWasqiypgikvrqlskllrgtkalteviplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvkl
interface signature	YYQWRQ/YYQW

Estimated binding specificities ?

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# IC=0.562 IC/col=0.035 n_of_columns=16

specificity:

A |  19  24  21  24  24  24  24  24  24  24  24  16  24  19  24  12
C |  38  24  23  24  24  24  24  24  24  24  24  16  24  20  24  12
G |  20  24  21  24  24  24  24  24  24  24  24  16  24  38  24  12
T |  19  24  31  24  24  24  24  24  24  24  24  48  24  19  24  60

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updated Wed Jun 24 09:28:21 2026