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legend  pdf

structure nameCRYSTAL STRUCTURE OF DNAA DOMAINIV COMPLEXED WITH DNAABOX DNA
(CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA)
referenceRIKEN Structural Genomics/Proteomics Initiative (RSGI)
sourceESCHERICHIA COLI
experimentX-ray (resolution=2.10, R-factor=0.229)
structural superfamilyTrpR-like;
sequence familyBacterial dnaA protein helixturnhelix;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRLPDHTTLH

Estimated binding specificities ?

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# IC=6.560 IC/col=0.937 n_of_columns=7 specificity:   
A |  67   0   9   0  96   9  96
C |  11   0  67  86   0  76   0
G |   9   0  11   1   0  11   0
T |   9  96   9   9   0   0   0
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: DNAA
TTATCCACAPubMed1j1v_A(9.05e-11)
TNCACAPubMed1j1v_A(7.04e-06)
TTGTCCACAPubMed1j1v_A(5.89e-07)
TTTTCCACAPubMed1j1v_A(5.89e-07)
TCCACAPubMed1j1v_A(9.80e-10)
CCGTTCACAPubMed1j1v_A(2.46e-03)
TCCCCAPubMed1j1v_A(7.57e-05)
TTATACACAPubMed1j1v_A(7.46e-06)
CCTGTGGATAACAPubMed1j1v_A(1.94e-09)
TGTGNATPubMed1j1v_A(2.82e-08)
TGTTATCCACAGGPubMed1j1v_A(1.94e-09)
TTNCACAPubMed1j1v_A(5.71e-05)
TTATCCAAAPubMed1j1v_A(3.45e-06)
TTCACPubMed1j1v_A(7.02e-03)
TGATCCACAPubMed1j1v_A(9.05e-11)
TGGATCAGPubMed1j1v_A(1.74e-04)
sitesourcematches (E-value)

Dendrogram of similar interfaces ?

matrix format
  
  RALTPTDCHGTCTCLTHT----------   L                 +-----------1j1v_A    
                                       +-----------3 
  ----------------NT----NAIARG   L     !           !          +1b72_B    
                                     +-4           +----------2 
  ----------------NT----NAITRG   L   ! !                      +5zjt_B    
                                     ! ! 
  ------HCRGRGQAQGKG----------   L --5 +-----------------------2glo_A    
                                     ! 
  ----------KGTCKGTCHT--------   L   !                         +4wuh_B    
                                     +-------------------------1 
  ------TC--KTTCKGTCHTST------   L                             +7ve5_B    
                                   

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updated Thu Sep 12 14:45:35 2024