1rtd_CD : 3D-footprint complex

structure name	STRUCTURE OF A CATALYTIC COMPLEX OF HIV-1 REVERSE TRANSCRIPTASE: IMPLICATIONS FOR NUCLEOSIDE ANALOG DRUG RESISTANCE
reference	Harrison et al. Science 282 1669 1998
source	HUMAN IMMUNODEFICIENCY VIRUS 1
experiment	X-ray (resolution=3.20, R-factor=?)
structural superfamily	DNA/RNA polymerases;Ribonuclease H-like;
reference complex	7ozw_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 1rtd_C interface=61,74,94,115,157,183,184,258,448,475, kispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvFaikkkdstkwrkLvdfrelnkrtqdfwevqlgIphpaglkkkksvtvldvgdaYfsvpldedfrkytaftipsinnetpgiryqynvlpqgwkgsPaifqssmtkilepfrkqnpdiviyqYMddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpivlpekdswtvndiCklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyqlekepivgaetfyvdgaanRetklgkagyvtnkgrqkvvpltdttnQktqlqaiylalqdsglevnivtdsqyalgiiqaqpdeseselvnqiieqlikkekvylawvpahkgiggneqvdklvsa > 1rtd_D interface= spietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaIkkkdstkwrklvDfrelnkrtqdfwevqlgipHpaglkkkksvtvldvgdayfSvpldedfrkytaftipsinnetpgiryqynvlpqgwkgspaIfqssmtkilepfrkqnpdiviyqymDDlyvgsdleigqhrtkieelrqhllrwglttpgyelhpdkwtvqpivlpekdswtvndiqklvgklnwasqiypGikvrqlckllrgtkalteviplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyql
interface signature	FLIYPYMCRQ/IDHSIDDG

Estimated binding specificities ?

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# IC=5.809 IC/col=0.323 n_of_columns=18

specificity:

A |   0   0   5  15  24  24  24  24  24  24  24  24  24  24  20  24   1  96
C |  90  96   5  11  24  24  24  24  24  24  24  24  24  24  10  24   5   0
G |   5   0  80  55  24  24  24  24  24  24  24  24  24  24  50  24  85   0
T |   1   0   6  15  24  24  24  24  24  24  24  24  24  24  16  24   5   0

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updated Wed Jun 24 11:30:04 2026