1tsr_B : 3D-footprint complex

structure name	P53 CORE DOMAIN IN COMPLEX WITH DNA (PROTEIN P53 TUMOR SUPPRESSOR)
reference	Pavletich et al. Science 265 346 1994
source	Homo sapiens
experiment	X-ray (resolution=2.20, R-factor=0.205)
structural superfamily	p53-like transcription factors;
sequence family	P53 DNAbinding domain;
redundant complexes	1tup
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 1tsr_B interface=25,153,181,182,185, svpsqktyqgsygfrlgflhsgtaKsvtctyspalnkmfcqlaktcpvqlwvdstpppgtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfrhsvvvpyeppevgsdcttihynymcnsscmggmnRrpiltiitledssgnllgrnsfevrvcACpgRdrrteeenl
interface signature	KRACR

Estimated binding specificities ?

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# IC=3.968 IC/col=0.794 n_of_columns=5

specificity:

A |  11   0  67   0  67
C |   9   0  11  96  11
G |  67  96   9   0   9
T |   9   0   9   0   9

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Dendrogram of similar interfaces ?

matrix format

  
  KG--------RTACCCRG--   L                                   +1tsr_B    
                                                           +-1 
  ------------ATCTRG--                                   +-2 +3us0_C    
                                                         ! ! 
  KGSGTG--KG--AGCCRGRT   L                       +-------3 +4ibu_A    
                                                 !       ! 
  KG--------RGATCTRG--   L   +-------------------5       +3q05_B    
                             !                   ! 
  KG----------ACCCRG--   L   !                   !      +3vd0_L    
                           --6                   +------4 
  ----------RGAGCCRG--   L   !                          +3exj_A    
                             ! 
  ------RG------------       +---------------------------2x6v_A

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updated Sun Jun 28 04:53:04 2026