1tup_B : 3D-footprint complex

structure name	TUMOR SUPPRESSOR P53 COMPLEXED WITH DNA (PROTEIN P53 TUMOR SUPPRESSOR )
reference	Pavletich et al.
source	Homo sapiens
experiment	X-ray (resolution=2.20, R-factor=0.202)
structural superfamily	p53-like transcription factors;
sequence family	P53 DNAbinding domain;
redundant complexes	1tsr
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 1tup_B interface=25,153,181,182,185, svpsqktyqgsygfrlgflhsgtaKsvtctyspalnkmfcqlaktcpvqlwvdstpppgtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfrhsvvvpyeppevgsdcttihynymcnsscmggmnRrpiltiitledssgnllgrnsfevrvcACpgRdrrteeenl
interface signature	KRACR

Estimated binding specificities ?

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# IC=4.316 IC/col=0.863 n_of_columns=5

specificity:

A |  24   0  60   0  48
C |   0   0   0  96  12
G |  72  96  36   0  24
T |   0   0   0   0  12

scan!

Dendrogram of similar interfaces ?

matrix format

  
  KG------RTACCCRG--   L       +1tup_B    
                             +-1 
  KGSGTGKG--AGCCRGRT   L   +-2 +4ibu_A    
                           ! ! 
  KG------RGATCTRG--   L --3 +3q05_B    
                           ! 
  --------RGAGCCRG--   L   +-3exj_A

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updated Sun Jun 28 04:53:34 2026