1yfh_AB : 3D-footprint complex

structure name	WT HUMAN O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE BOUND TO DNA CONTAINING AN ALKYLATED CYTOSINE
reference	Duguid et al. J.Mol.Biol. 350 657 2005
source	Homo sapiens
experiment	X-ray (resolution=3.01, R-factor=?)
structural superfamily	Methylated DNA-protein cysteine methyltransferase domain;Methylated DNA-protein cysteine methyltransferase, C-terminal domain;
reference complex	1yfh_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 1yfh_A interface=114,115, cemkrttldsplgklelsgceqglheikllgvpapaavlggpeplmqctawlnayfhqpeaieefpvpalhhpvfqqesftrqvlwkllkvvkfgevisyqqlaalagnpkaaRAvggamrgnpvpilipchrvvcssgavgnysgglavkewllaheghrlgkp > 1yfh_B interface=100,114,115,120,121,143,145, cemkrttldsplgklelsgceqglheikllgvpapaavlggpeplmqctawlnayfhqpeaieefpvpalhhpvfqqesftrqvlwkllkvvkfgevisYqqlaalagnpkaaRAvggaMRgnpvpilipchrvvcssgavgNySgglavkewllaheghr
interface signature	RA/YRAMRNS

Estimated binding specificities ?

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# IC=5.351 IC/col=0.595 n_of_columns=9

specificity:

A |   0   0  21  24  24  24  24   0   0
C |   0   0  21  24  24  24  24   0   0
G |  96  96  21  24  24  24  24  96   0
T |   0   0  33  24  24  24  24   0  96

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updated Wed Jun 24 12:06:40 2026