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structure nameTHE CRYSTAL STRUCTURE OF I-DMOI IN COMPLEX WITH DNA AND CA
(HOMING ENDONUCLEASE I-DMOI)
referenceMarcaida et al. Proc.Natl.Acad.Sci.USA 105 16888 2008
sourceDESULFUROCOCCUS MOBILIS
experimentX-ray (resolution=2.05, R-factor=0.189)
structural superfamilyHoming endonucleases;
redundant complexes2vs8_K 4d6n_F 4d6o_A 4una_A 4unb_G 4unc_G 4ut0_A 5a0w_A 5ak9_A 5akf_I 5akm_A 5akn_K 5o6g_A 5o6i_K
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureYLYRSERVTQVTRERSRRWDDRHV

Estimated binding specificities ?

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# IC=21.109 IC/col=1.173 n_of_columns=18 specificity:   
A |   0   0   0   0   0  96  96   0   1   9  67   0   0   0   0   0   0  96
C |   0  96  96   0   0   0   0  96   9  19   9  87  96  86   0   0  96   0
G |  96   0   0  96  96   0   0   0   0   9   9   0   0   0  96  96   0   0
T |   0   0   0   0   0   0   0   0  86  59  11   9   0  10   0   0   0   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  --YTLT--YC----RGSGECRGVTTG----QG--VG------TARTEARGSC--RGRGWCDCDCRGHAVC   L                 +---------2vs7_A    
                                                                               +-------------7 
  YGRGRG----------------QGEC--------------------------NT----------NCKT--   L   !             +---------3c0w_A    
                                                                               !  
  SANC--------------DAECNATG--RC--KGST--------------DA------------------   L   !               +-------2ex5_A    
                                                                               !               ! 
  STIT----------QT--ST--ATTC--------YT--SC----VCDTRGST------------------   L   !        +------6       +3mxb_B    
                                                                             -10        !      !     +-1 
  SGIG----------RG--QG--DGTA----YC--AT--SC----VCKGRG--------------------   L   !        !      +-----4 +6fb0_A    
                                                                               !        !            ! 
  SAYCLC--------------------NA--RG----RG------IC--RG--------------------   L   !   +----8            +-2fld_B    
                                                                               !   !    ! 
  CGRG--ST--TTKARG--QTFAQGNG------HC--SC--------QGRGQA------------------   L   !   !    !               +4yit_A    
                                                                               !   !    !             +-2 
  ST------------AT--LCYCECAT----YG--NA--SADC----KTKGSA------------------   L   +---9    +-------------3 +4lq0_A    
                                                                                   !                  ! 
  STIGRG--------LT--EC--STKG------TT--NA--------MGRTSC------------------   L       !                  +5t2n_A    
                                                                                   ! 
  CA----------------RT----FA----RG----RG--DT--MCEA----------------------   L       !                 +-5a74_B    
                                                                                   +-----------------5 
  SAIA----------RG--KG--QATA--------------------------------------------   L                         +-2vbl_B    
                                                                             

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updated Tue Dec 19 06:59:48 2023