3d0a_AC : 3D-footprint complex

structure name	HUMAN P53 CORE DOMAIN WITH HOT SPOT MUTATION R249S AND SECOND SITE SUPPRESSOR MUTATION H168R IN SEQUENCE-SPECIFIC COMPLEX WITH DNA
reference	Rozenberg et al. J.Mol.Biol. 385 249 2009
source	Homo sapiens
experiment	X-ray (resolution=1.80, R-factor=?)
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 3d0a_A interface=25,26,28,41,44,180,181,184, svpsqktyqgsygfrlgflhsgtaKSvTctyspalnkmfcQlaKtcpvqlwvdstpppgtrvramaiykqsqrmtevvrrcphhercdsdglappqhlirvegnlrveylddrntfrhsvvvpyeppevgsdcttihynymcnsscmggmnrspiltiitledssgnllgrnsfevrvcACpgRdrrteeenlrk > 3d0a_C interface=25,181,182,185, svpsqktyqgsygfrlgflhsgtaKsvtctyspalnkmfcqlaktcpvqlwvdstpppgtrvramaiykqsqrmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfrhsvvvpyeppevgsdcttihynymcnsscmggmnrspiltiitledssgnllgrnsfevrvcACpgRdrrteeen
interface signature	KSTQKACR/KACR

Estimated binding specificities ?

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# IC=11.475 IC/col=0.956 n_of_columns=12

specificity:

A |   8   0   0   0   6   0  24   6   6   0   0  78
C |   6   0  96  96  78   0  24   8   1   0  96   6
G |   6  96   0   0   6  96  24  76  83  96   0   6
T |  76   0   0   0   6   0  24   6   6   0   0   6

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updated Wed Jun 24 15:25:47 2026