| structure name | INTACT PPAR GAMMA - RXR ALPHA NUCLEAR RECEPTOR COMPLEX ON DNA BOUND WITH ROSIGLITAZONE, 9-CIS RETINOIC ACID AND NCOA2 PEPTIDE (PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA) |
| reference | Rastinejad et al. Nature 456 350 2008 |
| source | HOMO SAPIENS |
| experiment | X-ray (resolution=3.10, R-factor=?) |
| structural superfamily | Nuclear receptor ligand-binding domain;Glucocorticoid receptor-like DNA-binding domain; |
| sequence family | Zinc finger, C4 type two domains; Ligandbinding domain of nuclear hormon; |
| redundant complexes | 3dzu 3e00 |
| links to other resources | NAKB  PDIdb DNAproDB |
| protein sequence | |
| interface signature | EKRRFR |
Estimated binding specificities ?
| readout + contact |  |
A | 5 0 70 0 0 12 24 24 24 5 4 C | 4 0 16 96 96 16 24 24 24 4 4 G | 4 96 4 0 0 14 24 24 24 8 4 T | 83 0 6 0 0 54 24 24 24 79 84scan! |
Related DNA sequences reported in the literature ?
| site | source | matches (E-value) |
|---|---|---|
| term: RXR | ||
| AGGTCA | PubMed | 3dzy_D(5.85e-08), 3dzu_AD(5.13e-04), 3dzy_AD(3.73e-07), ... (total=5) |
| GGGTCA | PubMed | 3dzy_D(1.19e-04), 3dzu_AD(5.13e-04), 3dzy_AD(5.18e-04), ... (total=5) |
Dendrogram of similar interfaces ?
matrix format--ECKG--RGRG----FTRT L +----------------------3dzy_D ! ----KGVT--RG--KC---- L ! +------------1glu_A ! ! --ECKG--KGRG-------- L ! ! +1ynw_B +-8 ! +-1 --EAKG--RTRG-------- L ! ! +-----6 +-3 +1kb2_B ! ! ! ! ! ! CAECKG--KGRG-------- L ! ! ! ! +---4 +6l6q_B ! ! ! ! ! ! ----KGVG--RG-------- L ! ! ! +------5 +-5cbx_B --9 +---7 ! ----KAVG--RG-------- ! ! ! +5va7_A ! ! +-----2 --ECKG--KGRG-------- L ! ! +1r0n_A ! ! --EAKG--RTRTRT------ ! +------------------4umm_E ! --ECKG--KTRG-------- L +-----------------------2nll_A |
home
updated Mon Dec 16 20:43:53 2024