interface graph thumbnail
legend  pdf

structure nameINTACT PPAR GAMMA - RXR ALPHA NUCLEAR RECEPTOR COMPLEX ON DNA BOUND WITH GW9662, 9-CIS RETINOIC ACID AND NCOA2 PEPTIDE
(RETINOIC ACID RECEPTOR RXR-ALPHA)
referenceRastinejad et al. Nature 456 350 2008
sourceHOMO SAPIENS
experimentX-ray (resolution=3.10, R-factor=?)
structural superfamilyNuclear receptor ligand-binding domain;Glucocorticoid receptor-like DNA-binding domain;
sequence familyLigandbinding domain of nuclear hormon; Zinc finger, C4 type two domains;
redundant complexes3dzu 3dzy
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureEKKR

Estimated binding specificities ?

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# IC=3.142 IC/col=0.628 n_of_columns=5 specificity:   
A |  13   0  24  13  96
C |  13   0  24  54   0
G |  57  96  24  13   0
T |  13   0  24  16   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  --ECKG--KGRG----------   L                           +---3e00_A    
                                                     +-5 
  CAECKG--KGRG----------   L                  +------6 +---6l6q_B    
                                              !      ! 
  --ECKGAGKGRG----------   L                  !      +-----1hcq_E    
                                              ! 
  ----KGVT--RG----------   L                  !               +2c7a_B    
                               +--------------8             +-1 
  --EAKG--RTRTRT--------       !              !           +-2 +4umm_E    
                               !              !           ! ! 
  --EAKG--RTRTRT--------       !              !    +------3 +2han_B    
                               !              !    !      ! 
  ----KAVA--RA----------   L --9              +----7      +5e69_A    
                               !                   ! 
  --ECKGAG--RG----------   L   !                   !      +4ond_A    
                               !                   +------4 
  --ETKGAT--RG----------   L   !                          +1lat_A    
                               ! 
  --------------RAIAQTNA   L   +---------------------------6es3_K    
                             

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updated Thu Sep 12 17:05:06 2024