interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF MUTY BOUND TO ITS INHIBITOR DNA
(AG-specific adenine glycosylase)
referenceVerdine et al. Proc.Natl.Acad.Sci.Usa 106 18497 2009
sourceBacillus Stearothermophilus
experimentX-ray (resolution=2.20, R-factor=0.246)
structural superfamilyNudix;DNA-glycosylase;
sequence familyHhHGPD superfamily base excision DNA r; Helixhairpinhelix motif; Ironsulfur binding domain of endonucle;
redundant complexes1vrl 1rrq 3fsp 3fsq 1rrs
reference complex8dvp_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureQRYCSH

Estimated binding specificities ?

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# IC=2.540 IC/col=0.508 n_of_columns=5 specificity:   
A |   0  24   6  10  16
C |  96  24   6  10  19
G |   0  24  78  66  45
T |   0  24   6  10  16
scan!

Dendrogram of similar interfaces ?

matrix format
  
  QC--RGYC------------CASGHC   L              +-------------3g0q_A    
                                   +----------2 
  QGCGTA--------------------       !          !     +-------1orn_A    
                                 --3          +-----1 
  NG--RG--FGRC--------------       !                +-------4ejy_A    
                                   ! 
  ------------IAQTNAMC------   L   +------------------------2h1k_B

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updated Sat Aug 2 03:50:43 2025