3hk2_AB : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF T. THERMOPHILUS ARGONAUTE N478 MUTANT PROTEIN COMPLEXED WITH DNA GUIDE STRAND AND 19-NT RNA TARGET STRAND
reference	Patel et al. Nature 461 754 2009
source	THERMUS THERMOPHILUS
experiment	X-ray (resolution=2.80, R-factor=?)
structural superfamily	Ribonuclease H-like;
reference complex	4n41_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 3hk2_A interface= lgktevflnrfalrplnpeelrpwrlevvldpppgreevypllaqvarraggvtvrmgdglaswsppevlvlegtlarmgqtyayrlypkgrrpldpkdpgersvlsalarrllqerlrrlegvwveglavyrrehargpgwrvlggavldlwvsdsgafllevdpayrilcemsleawlaqghplpkrvrnaydrrtwellrlgeedpkelplpslldyhaskgrlqgreggrvawvadpkdprkpiphltgllvpvltlelpweerrrrtreiaswigrrlglgtpeavraqayrlsipklmgrravskpadalrvgfyraqetalallrldgaqgwpeflrrallrafgasgaslrlhtlhahpsqglafrealrkakeegvqavlvltppmawedrnrlkalllreglpsqilnvplreeerhrwenallgllakaglqvvalsgaypaelavgfnaggresfrfggaacavggdgghllwtlpeaqageripqevvwdlleetlwafrrkagrlpsrvlllrdgrvpqdefalalealaregiaydlvsvrksgggrvypvqgrladglyvpledktfllltvhrgtprplklvheagdtplealahqifhltrlypasgfafprlpaplhladrlvkevgrlgirhlkevdreklffv > 3hk2_B interface= lgktevflnrfalrplnpeelrpwrlevvldpppgreevypllaqvarraggvtvrmgdglaswsppevlvlegtlarmgqtyayrlypkgrrpldpkdpgersvlsalarrllqerlrrlegvwveglavyrrehargpgwrvlggavldlwvsdsgafllevdpayrilcemsleawlaqghplpkrvrnaydrrtwellrlgeedpkelplpslldyhaskgrlqgreggrvawvadpkdprkpiphltgllvpvltleslpweerrrrtreiaswigrrlglgtpeavraqayrlsipklmgrravskpadalrvgfyraqetalallrldgaqgwpeflrrallrafgasgaslrlhtlhahpsqglafrealrkakeegvqavlvltppmawedrnrlkalllreglpsqilnvplreeerhrwenallgllakaglqvvalsgaypaelavgfnaggresfrfggaacavggdgghllwtlpeaqageripqevvwdlleetlwafrrkagrlpsrvlllrdgrvpqdefalalealaregiaydlvsvrksgggrvypvqgrladglyvpledktfllltvhrrgtprplklvheagdtplealahqifhltrlypasgfafprlpaplhladrlvkevgrlgirhlkevdreklffv
interface signature	/

Estimated binding specificities ?

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# IC=4.166 IC/col=0.260 n_of_columns=16

specificity:

A |   0   0  31  24  16  24  24  24  24  24  24  24  24  21  24   0
C |   0   0  21  24  16  24  24  24  24  24  24  24  24  23  24   0
G |   0  96  21  24  48  24  24  24  24  24  24  24  24  21  24   0
T |  96   0  23  24  16  24  24  24  24  24  24  24  24  31  24  96

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updated Tue Jul 29 20:44:21 2025