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structure nameCRYSTAL STRUCTURE OF RESTRICTION ENDONUCLEASE ECORII N-TERMINAL EFFECTOR-BINDING DOMAIN IN COMPLEX WITH COGNATE DNA
(Restriction endonuclease)
referenceTamulaitiene et al.
sourceEscherichia coli
experimentX-ray (resolution=2.51, R-factor=0.191)
structural superfamilyDNA-binding pseudobarrel domain;
sequence familyRestriction endonuclease EcoRII, Nterminal;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNHQVYYTRER

Estimated binding specificities ?

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# IC=6.530 IC/col=0.933 n_of_columns=7 specificity:   
A |  17   1   0   0   0   0  17
C |  61  61  96   0   0   0  63
G |  10   8   0   0  96  96   8
T |   8  26   0  96   0   0   8
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: EcoRII
CCNGGPubMed3hqf_A(1.00e-03)
CCAGGPubMed3hqf_A(7.02e-07)
CCTGGPubMed3hqf_A(7.02e-07)
ACTGGGPubMed3hqf_A(3.37e-03)
CCGGGPubMed3hqf_A(6.03e-03)
CCNGGAPubMed3hqf_A(3.37e-03)

Dendrogram of similar interfaces ?

matrix format
  
  ----NA--HGQAVC--YGYC----TGRGECRT   L              +-------3hqf_A    
                                               +----2 
  --NA------RGHG--LC------RGYGECRT   L       +-3    +-------5o63_B    
                                             ! ! 
  KA----ST--LT--RGITWC--------MA--   L   +---4 +------------6j9b_A    
                                         !   ! 
  ------ST------RG--WCNC------MA--   L   !   !           +-6j9c_D    
                                       --5   +-----------1 
  ------ST--IT--RGVTWC--------MA--   L   !               +-5yzz_C    
                                         ! 
  ----------IT--RGVTWCNCNT----MA--   L   +-----------------6fas_B    
                                       

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updated Fri Sep 13 17:05:26 2024