structure name	CRYSTAL STRUCTURE OF T. THERMOPHILUS ARGONAUTE COMPLEXED WITH DNA GUIDE STRAND AND 19-NT RNA TARGET STRAND WITH TWO MG2+ AT THE CLEAVAGE SITE
reference	Patel et al. Nature 461 754 2009
source	THERMUS THERMOPHILUS
experiment	X-ray (resolution=3.21, R-factor=?)
structural superfamily	Ribonuclease H-like;
reference complex	4n41_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 3hvr_A interface= hlgktevflnrfalrplnpeelrpwrlevvldpppgreevypllaqvarraggvtvrmgdglaswsppevlvlegtlarmgqtyayrlypkgrrpldpkdpgersvlsalarrllqerlrrlegvwveglavyrrehargpgwrvlggavldlwvsdsgafllevdpayrilcemsleawlaqghplpkrvrnaydrrtwellrlgeedpkelplplslldyhaskgrlqgreggrvawvadkpiphtgllvpvltledlslpweerrrrtreiaswigrrlglgtpeavraqayrlsipklmgrravskpadalrvgfyraqetalallrldgaqgwpeflrrallrafgasgaslrlhtlhahpsqglafrealrkakeegvqavlvltppmawedrnrlkalllreglpsqilnvplreeerhrwenallgllakaglqvvalsgaypaelavgfdaggresfrfggaacavgghllwtlpeaqageripqevvwdlleetlwafrrkagrlpsrvlllrdgrvpqdefalalealaregiaydlvsvrksgggrvypvqgrladglyvpledktfllltvhrgtprplklvheagdtplealahqifhltrlypasgfafprlpaplhladrlvkevgrlgirhlkevdreklffv > 3hvr_B interface= lgktevflnrfalrplnpeelrpwrlevvldpppgreevypllaqvarraggvtvrmgdglaswsppevlvlegtlarmgqtyayrlypkgrrpldpkdpgersvlsalarrllqerlrrlegvwveglavyrrehargpgwrvlggavldlwvsdsgafllevdpayrilcemsleawlaqghplpkrvrnaydrrtwellrlgeedpkelplpslldyhaskgrlqgreggrvawvadrkpiphltgllvpvltlelslpweerrrrtreiaswigrrlglgtpeavraqayrlsipklmgrravskpadalrvgfyraqetalallrldgaqgwpeflrrallrafgasgaslrlhtlhahpsqglafrealrkakeegvqavlvltppmawedrnrlkalllreglpsqilnvplreeerhrwenallgllakaglqvvalsgaypaelavgfdagesfrfggaacavggdhllwtlpeaqageripqevvwdlleetlwafrrkagrlpsrvlllrdgrvpqdefalalealaregiaydlvsvrksgggrvypvqgrladglyvpledktfllltvhgtprplklvheagdtplealahqifhltrlypasgfafprlpaplhladrlvkevgrlgirhlkevdreklffv

No structural evidence for specific binding to DNA (<4 informative columns)

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updated Mon Jan 5 04:15:44 2026