3hvr_AB : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF T. THERMOPHILUS ARGONAUTE COMPLEXED WITH DNA GUIDE STRAND AND 19-NT RNA TARGET STRAND WITH TWO MG2+ AT THE CLEAVAGE SITE
reference	Patel et al. Nature 461 754 2009
source	THERMUS THERMOPHILUS
experiment	X-ray (resolution=3.21, R-factor=?)
structural superfamily	Ribonuclease H-like;
reference complex	4n41_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 3hvr_A interface= hlgktevflnrfalrplnpeelrpwrlevvldpppgreevypllaqvarraggvtvrmgdglaswsppevlvlegtlarmgqtyayrlypkgrrpldpkdpgersvlsalarrllqerlrrlegvwveglavyrrehargpgwrvlggavldlwvsdsgafllevdpayrilcemsleawlaqghplpkrvrnaydrrtwellrlgeedpkelplplslldyhaskgrlqgreggrvawvadkpiphtgllvpvltledlslpweerrrrtreiaswigrrlglgtpeavraqayrlsipklmgrravskpadalrvgfyraqetalallrldgaqgwpeflrrallrafgasgaslrlhtlhahpsqglafrealrkakeegvqavlvltppmawedrnrlkalllreglpsqilnvplreeerhrwenallgllakaglqvvalsgaypaelavgfdaggresfrfggaacavgghllwtlpeaqageripqevvwdlleetlwafrrkagrlpsrvlllrdgrvpqdefalalealaregiaydlvsvrksgggrvypvqgrladglyvpledktfllltvhrgtprplklvheagdtplealahqifhltrlypasgfafprlpaplhladrlvkevgrlgirhlkevdreklffv > 3hvr_B interface= lgktevflnrfalrplnpeelrpwrlevvldpppgreevypllaqvarraggvtvrmgdglaswsppevlvlegtlarmgqtyayrlypkgrrpldpkdpgersvlsalarrllqerlrrlegvwveglavyrrehargpgwrvlggavldlwvsdsgafllevdpayrilcemsleawlaqghplpkrvrnaydrrtwellrlgeedpkelplpslldyhaskgrlqgreggrvawvadrkpiphltgllvpvltlelslpweerrrrtreiaswigrrlglgtpeavraqayrlsipklmgrravskpadalrvgfyraqetalallrldgaqgwpeflrrallrafgasgaslrlhtlhahpsqglafrealrkakeegvqavlvltppmawedrnrlkalllreglpsqilnvplreeerhrwenallgllakaglqvvalsgaypaelavgfdagesfrfggaacavggdhllwtlpeaqageripqevvwdlleetlwafrrkagrlpsrvlllrdgrvpqdefalalealaregiaydlvsvrksgggrvypvqgrladglyvpledktfllltvhgtprplklvheagdtplealahqifhltrlypasgfafprlpaplhladrlvkevgrlgirhlkevdreklffv
interface signature	/

Estimated binding specificities ?

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# IC=3.113 IC/col=0.195 n_of_columns=16

specificity:

A |   0   0  24  24  24  24  24  24  24  24  24  24  16  24  24  12
C |   0   0  24  24  24  24  24  24  24  24  24  24  16  24  24  12
G |   0  96  24  24  24  24  24  24  24  24  24  24  16  24  24  12
T |  96   0  24  24  24  24  24  24  24  24  24  24  48  24  24  60

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updated Tue Jul 29 20:52:10 2025