3hxo_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF VON WILLEBRAND FACTOR (VWF) A1 DOMAIN IN COMPLEX WITH DNA APTAMER ARC1172, AN INHIBITOR OF VWF-PLATELET BINDING (von Willebrand factor)
reference	Fremont et al.
source	Homo sapiens
experiment	X-ray (resolution=2.40, R-factor=0.230)
structural superfamily	vWA-like;
sequence family	von Willebrand factor type A domain;
redundant complexes	3hxq_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 3hxo_A interface=18,97,119,121,122,123,125,126,127,128,129,152,153,154,158, fycsrlldlvflldgssRlseaefevlkafvvdmmerlrisqkwvrvavveyhdgshayiglkdrkrpselrriasqvkyagsqvastsevlkytlFqifskidrpeasrialllmasQePQRmSRNFVryvqglkkkkvivipvgigphaNLKqirLiekqapenkafvlssvdeleqqrdeivsylcdlapeapppt
interface signature	RFQPQRSRNFVNLKL

Estimated binding specificities ?

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# IC=16.482 IC/col=0.634 n_of_columns=26

specificity:

A |   9  96  24   0  24  24  24  24  24  24  24  24  24  24  19   0  24   0   0   0   0   0   0   0   0   0
C |  67   0  24   0  24  24  24  24  24  24  24  24  24  24  19   0  24  96   0   0   0   0  96  96   0  96
G |   9   0  24   0  24  24  24  24  24  24  24  24  24  24  39   0  24   0  96  96   0  96   0   0   0   0
T |  11   0  24  96  24  24  24  24  24  24  24  24  24  24  19  96  24   0   0   0  96   0   0   0  96   0

scan!

Dendrogram of similar interfaces ?

matrix format

  
  ------MTLTKT--         +-----------------------------1jey_B    
                       +-3 
  --QC----------   L   ! !       +---------------------1fiu_B    
                       ! +-------2 
  SCNGNG--------   L --4         +---------------------3v1z_B    
                       ! 
  ------------QT       !                            +6ne3_W    
                       +----------------------------1 
  ------------ST                                    +6jyl_K

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updated Sun Aug 3 06:54:04 2025