3kle_AB : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF AZT-RESISTANT HIV-1 REVERSE TRANSCRIPTASE CROSSLINKED TO A DSDNA WITH A BOUND EXCISION PRODUCT, AZTPPPPA
reference	Sarafianos et al. Nat.Struct.Mol.Biol. 17 1202 2010
source	HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
experiment	X-ray (resolution=3.20, R-factor=?)
structural superfamily	DNA/RNA polymerases;Ribonuclease H-like;
reference complex	7ozw_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 3kle_A interface=94,183,356,448, pispietvpvklkpgmdgpkvkqwplteekikalveictelekegkiskigpenpyntpvfaikkknstrwrklvdfrelnkrtqdfwevqlgIphpaglkkkksvtvldvgdayfsvpldedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdiviyqYmddlyvgsdleigqhrtkieelrqhllrwglytpdqkhqkeppflwmgyelhpdkwtvqpivlpekdswtvndicklvgklnwasqiypgikvrqlskllrgtkalteviplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyaRmrgahtndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyqlekepivgaetfyvdgaanRetklgkagyvtnkgrqkvvpltnttnqktelqaiylalqdsglevnivtdsqyalgiiqaqpdkseselvnqiieqlikkekvylawvpahkgiggneqvdklvsagirkvl > 3kle_B interface= spietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikkkdstkwrklvdfrelnkrtqdfwevqlgipHpaglkkkksvtvldvgdayfsvpldedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdiviyqymDdlyvgsdleigqhrtkieelrqhllrwglttpdkkhqgyelhpdkwtvqpivlpekdswtvndiqklvgklnwasqiypgikvrqlskllrgtkalteviplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvKqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyqgghhhhh
interface signature	IYRR/HDK

Estimated binding specificities ?

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# IC=2.689 IC/col=0.168 n_of_columns=16

specificity:

A |  11   8  24  24  24  24  24  24  24  24  24  24  24  24  10   0
C |   8   8  24  24  24  24  24  24  24  24  24  24  24  24  61  96
G |  69   8  24  24  24  24  24  24  24  24  24  24  24  24   8   0
T |   8  72  24  24  24  24  24  24  24  24  24  24  24  24  17   0

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updated Mon Jan 5 04:40:51 2026