3kle_MN : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF AZT-RESISTANT HIV-1 REVERSE TRANSCRIPTASE CROSSLINKED TO A DSDNA WITH A BOUND EXCISION PRODUCT, AZTPPPPA
reference	Sarafianos et al. Nat.Struct.Mol.Biol. 17 1202 2010
source	HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
experiment	X-ray (resolution=3.20, R-factor=?)
structural superfamily	DNA/RNA polymerases;Ribonuclease H-like;
reference complex	7ozw_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 3kle_M interface=94,183,448, pispietvpvklkpgmdgpkvkqwplteekikalveictelekegkiskigpenpyntpvfaikkknstrwrklvdfrelnkrtqdfwevqlgIphpaglkkkksvtvldvgdayfsvpldedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdiviyqYmddlyvgsdleigqhrtkieelrqhllrwglytpdqkhqkeppflwmgyelhpdkwtvqpivlpekdswtvndicklvgklnwasqiypgikvrqlskllrgtkalteviplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyqlekepivgaetfyvdgaanRetklgkagyvtnkgrqkvvpltnttnqktelqaiylalqdsglevnivtdsqyalgiiqaqpdkseselvnqiieqlikkekvylawvpahkgiggneqvdklvsagirkvl > 3kle_N interface= spietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikkkdstkwrklvdfrelnkrtqdfwevqlgipHpaglkkkksvtvldvgdayfsvpldedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdiviyqymDdlyvgsdleigqhrtkieelrqhllrwglttpdkkhqgyelhpdkwtvqpivlpekdswtvndiqklvgklnwasqiypgikvrqlskllrgtkalteviplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyqg
interface signature	IYR/HD

Estimated binding specificities ?

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# IC=2.674 IC/col=0.167 n_of_columns=16

specificity:

A |   9   9  24  24  24  24  24  24  24  24  24  24  24  24  11   0
C |   9   9  24  24  24  24  24  24  24  24  24  24  24  24  67  96
G |  69  11  24  24  24  24  24  24  24  24  24  24  24  24   9   0
T |   9  67  24  24  24  24  24  24  24  24  24  24  24  24   9   0

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updated Mon Jan 5 04:42:09 2026