3klh_AB : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF AZT-RESISTANT HIV-1 REVERSE TRANSCRIPTASE CROSSLINKED TO POST-TRANSLOCATION AZTMP-TERMINATED DNA (COMPLEX P)
reference	Sarafianos et al. Nat.Struct.Mol.Biol. 17 1202 2010
source	HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
experiment	X-ray (resolution=2.90, R-factor=?)
structural superfamily	DNA/RNA polymerases;Ribonuclease H-like;
reference complex	7ozw_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 3klh_A interface=94,157,183,184,265,356,358,448, pispietvpvklkpgmdgpkvkqwplteekikalveictelekegkiskigpenpyntpvfaikkknstrwrklvdfrelnkrtqdfwevqlgIphpaglkkkksvtvldvgdayfsvpldedfrkytaftipsinnetpgiryqynvlpqgwkgsPaifqssmtkilepfkkqnpdiviyqYMddlyvgsdleigqhrtkieelrqhllrwglytpdqkhqkeppflwmgyelhpdkwtvqpivlpekdswtvndicklvgklNwasqiypgikvrqlskllrgtkalteviplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyaRmRgahtndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyqlekepivgaetfyvdgaanRetklgkagyvtnkgrqkvvpltnttnqktelqaiylalqdsglevnivtdsqyalgiiqaqpdkseselvnqiieqlikkekvylawvpahkgiggneqvdklvsagirk > 3klh_B interface= pispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikkkdstkwrklvdfrelnkrtqdfwevqlgIphpaglkkkksvtvldvgdayfsvpldedfrkytaftipsinnetpgiryqynvlpqgwkgsPaifqssmtkilepfkkqnpdiviyqYMddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpivlpekdswtvndiqklvgklNwasqiypgikvrqlskllrgtkalteviplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyaRmRgahtndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyq
interface signature	IPYMNRRR/IPYMNRR

Estimated binding specificities ?

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# IC=3.955 IC/col=0.233 n_of_columns=17

specificity:

A |   0   9   9  24  24  24  24  24  24  24  24  24  24  24  24   0   0
C |   7   7  51  24  24  24  24  24  24  24  24  24  24  24  24  81  96
G |  88   7  22  24  24  24  24  24  24  24  24  24  24  24  24   8   0
T |   1  73  14  24  24  24  24  24  24  24  24  24  24  24  24   7   0

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updated Mon Jan 5 04:46:08 2026