interface graph thumbnail
legend  pdf

structure nameSTRUCTURE OF THE LARGE FRAGMENT OF THERMUS AQUATICUS DNA POLYMERASE I IN COMPLEX WITH A BLUNT-ENDED DNA AND DDATP
(DNA polymerase I, thermostable)
referenceDiederichs et al. 'Embo 29 1738 2010
sourceThermus aquaticus
experimentX-ray (resolution=2.19, R-factor=0.186)
structural superfamilyDNA/RNA polymerases;Ribonuclease H-like;
sequence familyDNA polymerase family A; Taq polymerase, exonuclease;
redundant complexes4ktq 3ktq 1qsy 1qss 1tau 3lwl 1qtm 2ktq
reference complex6fbc_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKTYRNNRH

Estimated binding specificities ?

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# IC=3.142 IC/col=0.786 n_of_columns=4 specificity:   
A |  16  13   0   0
C |  13  57   0  96
G |  54  13  96   0
T |  13  13   0   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  --------------------------KC--YG------RGNGNGRC------YTMTRT--------------------QT--HG   L                                +3lwm_A    
                                                                                                                        +-1 
  --------------DTKT--------KC----------RG--NTRGAAFA--YCIA--LAQTNANT------------QC----   L                       +------2 +2hhv_A    
                                                                                                                 !      ! 
  LCNGKGYGMGRCEG------------------SGHGVC----------------------------------------------            +--------------3      +-1kln_A    
                                                                                                  !              ! 
  ----------------------------KT--------RTNG----------YA------------------------QA----       +----4              +--------1x9m_A    
                                                                                             !    ! 
  ------------------ATYTDGKG------------------------TTYT--------------------------HT--   L --5    +-----------------------1msw_D    
                                                                                             ! 
  ------------------------------------------------------------------SCTAKTVCHTKG------   L   +----------------------------1je8_F    
                                                                                           

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updated Thu Sep 12 17:36:56 2024