3m8r_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF THE LARGE FRAGMENT OF DNA POLYMERASE I FROM THERMUS AQUATICUS IN A CLOSED TERNARY COMPLEX WITH TRAPPED 4'- ETHYLATED DTTP (DNA polymerase I, thermostable)
reference	Diederichs et al. Angew.Chem.Int.Ed.Engl. 49 5181 2010
source	Thermus aquaticus
experiment	X-ray (resolution=2.00, R-factor=0.182)
structural superfamily	DNA/RNA polymerases;Ribonuclease H-like;
sequence family	DNA polymerase family A; Taq polymerase, exonuclease;
redundant complexes	3m8s 4ktq 3lwm 3ktq 1qsy 1qss 1tau 3lwl 1qtm 2ktq
reference complex	6fbc_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 3m8r_A interface=247,251,280,287,290,491, leeapwpppegafvgfvlsrkepmwadllalaaarggrvhrapepykalrdlkeargllakdlsvlalreglglppgddpmllaylldpsnttpegvarryggewteeageraalserlfanlwgrlegeerllwlyreverplsavlahmeatgvrldvaylralslevaeeiarleaevfrlaghpfnlnsrdqlervlfdelglpaigktektgkrstsaavlealreahpivekilqyreltKlksTyidplpdlihprtgrlhtrfnqtatatgRlsssdpNlqNipvrtplgqrirrafiaeegwllvaldysqielrvlahlsgdenlirvfqegrdihtetaswmfgvpreavdplmrraaktinfgvlygmsahrlsqelaipyeeaqafieryfqsfpkvrawiektleegrrrgyvetlfgrrryvpdlearvksvreaaermafnmpvqgtaadlmklamvklfprleemgarmllqvHdelvleapkeraeavarlakevmegvyplavplevevgigedwlsake
interface signature	KTRNNH

Estimated binding specificities ?

contact

# IC=2.635 IC/col=0.659 n_of_columns=4

specificity:

A |   9   0   9   9
C |   9  96  11  67
G |  67   0  67   9
T |  11   0   9  11

scan!

Dendrogram of similar interfaces ?

matrix format

  
  ------------IASAAAVAAA--------KC----------RG--NGNG--TAFA--YAMASAHARA--QAEA--RANGQG--HG   L                       +---3m8r_A    
                                                                                                              +----2 
  ----------------DT--KT--------KC----------RG----NTRGAAFA--YCIA------LAQTNANT----QC----   L                  !    ! +-2hhv_A    
                                                                                               +--------------3    +-1 
  LCNGKGYGMGEG----------------------SGHGVC----------------------------------------------       !              !      +-1kln_A    
                                                                                             --4              ! 
  --------------------------------KT--------RT--NG----------YA--------------------QA----       !              +--------1x9m_A    
                                                                                               ! 
  ----------------------ATYTDGKG----------RCRCYC----------TTYT----------------------HT--   L   +-----------------------1msw_D

home
updated Thu Sep 12 17:38:50 2024