interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF THE LARGE FRAGMENT OF DNA POLYMERASE I FROM THERMUS AQUATICUS IN A CLOSED TERNARY COMPLEX WITH TRAPPED 4'- ETHYLATED DTTP
(DNA polymerase I, thermostable)
referenceDiederichs et al. Angew.Chem.Int.Ed.Engl. 49 5181 2010
sourceThermus aquaticus
experimentX-ray (resolution=2.00, R-factor=0.182)
structural superfamilyDNA/RNA polymerases;Ribonuclease H-like;
sequence familyDNA polymerase family A; Taq polymerase, exonuclease;
redundant complexes3m8s 4ktq 3lwm 3ktq 1qsy 1qss 1tau 3lwl 1qtm 2ktq
reference complex6fbc_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKTRNNH

Estimated binding specificities ?

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# IC=2.714 IC/col=0.678 n_of_columns=4 specificity:   
A |   9   9   0   9
C |   9  67   0  69
G |  69  11  96   9
T |   9   9   0   9
scan!

Dendrogram of similar interfaces ?

matrix format
  
  ------------IASAAAVAAA--------KC----------RG--NGNG--TAFA--YAMASAHARA--QAEA--RANGQG--HG   L                       +---3m8r_A    
                                                                                                              +----2 
  ----------------DT--KT--------KC----------RG----NTRGAAFA--YCIA------LAQTNANT----QC----   L                  !    ! +-2hhv_A    
                                                                                               +--------------3    +-1 
  LCNGKGYGMGEG----------------------SGHGVC----------------------------------------------       !              !      +-1kln_A    
                                                                                             --4              ! 
  --------------------------------KT--------RT--NG----------YA--------------------QA----       !              +--------1x9m_A    
                                                                                               ! 
  ----------------------ATYTDGKG----------RCRCYC----------TTYT----------------------HT--   L   +-----------------------1msw_D    
                                                                                             

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updated Mon Dec 18 08:27:31 2023