| structure name | STRUCTURAL BASIS FOR PROFICIENT INCORPORATION OF DTTP OPPOSITE O6- METHYLGUANINE BY HUMAN DNA POLYMERASE IOTA (DNA POLYMERASE IOTA) |
| reference | J.Biol.Chem. 285 40666 2010 X-RAY DIFFRACTION |
| source | HOMO SAPIENS |
| experiment | X-ray (resolution=1.90, R-factor=0.210) |
| structural superfamily | DNA/RNA polymerases;Lesion bypass DNA polymerase Y-family, little finger domain; |
| sequence family | impB/mucB/samB family; |
| redundant complexes | 3ngd 3h4b 3h4d 2alz 3epg 3epi 3gv5 3gv8 1t3n 4ebd 4ebe 3g6v 5ulw 3g6x 5ulx 4fs1 3q8p 3g6y 4fs2 3q8q 2fln 3q8r 3q8s 4ebc 1zet 2flp 2fll 2dpj 3gv7 5kt2 5kt3 5kt4 5kt5 5kt6 4eyh 5kt7 4eyi 2dpi 3h40 |
| links to other resources | NAKB  PDIdb DNAproDB |
| protein sequence |
No structural evidence for specific binding to DNA (<4 informative columns)
Dendrogram of similar interfaces ?
matrix format--YG------------------------------EG------RA--QA------ +---3osn_A +-6 ------IT--------------------------ST--------RC-------- ! +---7m7n_A +---------8 ----MASA----AAPC--IC--------------EG--------TG------RG ! ! +-2oh2_B ! +---4 ----MA--------PAFAIA--------------EC--------TG-------- ! +-7nv0_A ! ----AC----AG--------------------ST--YG--RG--------RCKT +--------9 +4f4z_A ! ! +-1 ----AGAG------PC----MG------------IC------HA------RGRG ! ! +-3 +4f4w_A ! ! ! ! ----VASA----AAPT--MT--------------EG----RT------RT---- ! ! +-5 +5yuy_A +-10 ! ! ! ----EG--------FG------------------ET--YG-------------- ! ! +-----------7 +-3gqc_A ! ! ! FCYC----TTAT----------SCICDCEC--ST----------------RCRT ! ! +---4tqr_A -11 ! ------------------------------RG---------------------- ! +------------------------5tw1_T ! ------------------------------RT---------------------- ! +3n4m_B +------------------------2 ------------------------------RA---------------------- +6b6h_I |
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updated Thu Sep 12 17:50:20 2024