3us0_ABCD : 3D-footprint complex

structure name	STRUCTURE OF P63 DNA BINDING DOMAIN IN COMPLEX WITH A 22 BASE PAIR A/T RICH RESPONSE ELEMENT CONTAINING A TWO BASE PAIR "AT" SPACER BETWEEN HALF SITES
reference	Herzberg et al. J.Biol.Chem. 287 7477 2012
source	Homo sapiens
experiment	X-ray (resolution=2.50, R-factor=?)
structural superfamily	p53-like transcription factors;
reference complex	3qyn_C
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 3us0_A interface=182,183,186, spsntdypgphsfdvsfqqsstaksatwtystelkklycqiaktcpiqikvmtpppqgavirampvykkaehvtevvkrcpnhelsrefnegqiappshlirvegnshaqyvedpitgrqsvlvpyeppqvgtefttvlynfmcnsscvggmnrrpiliivtletrdgqvlgrrcfearicACpgRdrkadedsi > 3us0_B interface=178,179,182, maspsntdypgphsfdvsfqsatwtystelkklycqiaktcpiqikvmtpppqgavirampvykkaehvtevvkrcpnhelsrefnegqiappshlirvegnshaqyvedpitgrqsvlvpyeppqvgtefttvlynfmcnsscvggmnrrpiliivtletrdgqvlgrrcfearicACpgRdrkadedsirk > 3us0_C interface=183,184,187, aspsntdypgphsfdvsfqqsstaksatwtystelkklycqiaktcpiqikvmtpppqgavirampvykkaehvtevvkrcpnhelsrefnegqiappshlirvegnshaqyvedpitgrqsvlvpyeppqvgtefttvlynfmcnsscvggmnrrpiliivtletrdgqvlgrrcfearicACpgRdrkadedsi > 3us0_D interface=177,178,181, maspsntdypgphsfdvsfqatwtystelkklycqiaktcpiqikvmtpppqgavirampvykkaehvtevvkrcpnhelsrefnegqiappshlirvegnshaqyvedpitgrqsvlvpyeppqvgtefttvlynfmcnsscvggmnrrpiliivtletrdgqvlgrrcfearicACpgRdrkadedsirk
interface signature	ACR/ACR/ACR/ACR

Estimated binding specificities ?

readout + contact

# IC=9.654 IC/col=0.603 n_of_columns=16

specificity:

A |   0  79   5   0  11  24  24  24  24  24  24  67   0  84   0   0
C |  96   7  11   0  11  24  24  24  24  24  24  13  96   5   0   0
G |   0   5   7  96  11  24  24  24  24  24  24   5   0   7   0  96
T |   0   5  73   0  63  24  24  24  24  24  24  11   0   0  96   0

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updated Mon Sep 9 20:12:56 2024