3us0_ABCD : 3D-footprint complex

structure name	STRUCTURE OF P63 DNA BINDING DOMAIN IN COMPLEX WITH A 22 BASE PAIR A/T RICH RESPONSE ELEMENT CONTAINING A TWO BASE PAIR "AT" SPACER BETWEEN HALF SITES
reference	Herzberg et al. J.Biol.Chem. 287 7477 2012
source	Homo sapiens
experiment	X-ray (resolution=2.50, R-factor=?)
structural superfamily	p53-like transcription factors;
reference complex	3qyn_C
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 3us0_A interface=182,183,186, spsntdypgphsfdvsfqqsstaksatwtystelkklycqiaktcpiqikvmtpppqgavirampvykkaehvtevvkrcpnhelsrefnegqiappshlirvegnshaqyvedpitgrqsvlvpyeppqvgtefttvlynfmcnsscvggmnrrpiliivtletrdgqvlgrrcfearicACpgRdrkadedsi > 3us0_B interface=178,179,182, maspsntdypgphsfdvsfqsatwtystelkklycqiaktcpiqikvmtpppqgavirampvykkaehvtevvkrcpnhelsrefnegqiappshlirvegnshaqyvedpitgrqsvlvpyeppqvgtefttvlynfmcnsscvggmnrrpiliivtletrdgqvlgrrcfearicACpgRdrkadedsirk > 3us0_C interface=183,184,187, aspsntdypgphsfdvsfqqsstaksatwtystelkklycqiaktcpiqikvmtpppqgavirampvykkaehvtevvkrcpnhelsrefnegqiappshlirvegnshaqyvedpitgrqsvlvpyeppqvgtefttvlynfmcnsscvggmnrrpiliivtletrdgqvlgrrcfearicACpgRdrkadedsi > 3us0_D interface=177,178,181, maspsntdypgphsfdvsfqatwtystelkklycqiaktcpiqikvmtpppqgavirampvykkaehvtevvkrcpnhelsrefnegqiappshlirvegnshaqyvedpitgrqsvlvpyeppqvgtefttvlynfmcnsscvggmnrrpiliivtletrdgqvlgrrcfearicACpgRdrkadedsirk
interface signature	ACR/ACR/ACR/ACR

Estimated binding specificities ?

readout + contact

# IC=9.944 IC/col=0.621 n_of_columns=16

specificity:

A |   0  79   1   0  11  24  24  24  24  24  24  73   0  79   0   0
C |  96   5  11   0  13  24  24  24  24  24  24  12  96   5   0   0
G |   0   5   5  96   5  24  24  24  24  24  24   0   0   5   0  96
T |   0   7  79   0  67  24  24  24  24  24  24  11   0   7  96   0

scan!

home
updated Tue Jul 29 23:14:00 2025