3us2_ABCD : 3D-footprint complex

structure name	STRUCTURE OF P63 DNA BINDING DOMAIN IN COMPLEX WITH A 19 BASE PAIR A/T RICH RESPONSE ELEMENT CONTAINING TWO HALF SITES WITH A SINGLE BASE PAIR OVERLAP
reference	Herzberg et al. J.Biol.Chem. 287 7477 2012
source	Homo sapiens
experiment	X-ray (resolution=4.20, R-factor=?)
structural superfamily	p53-like transcription factors;
reference complex	3qyn_C
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 3us2_A interface=181,182,185, spsntdypgphsfdvsfqqsstksatwtystelkklycqiaktcpiqikvmtpppqgavirampvykkaehvtevvkrcpnhelsrefnegqiappshlirvegnshaqyvedpitgrqsvlvpyeppqvgtefttvlynfmcnsscvggmnrrpiliivtletrdgqvlgrrcfearicACpgRdrkadeds > 3us2_B interface=169,170,173, dypgphsfdvsfqtwtystelkklycqiaktcpiqikvmtpppqgavirampvykkaehvtevvkrcpnhelsrefnegqiappshlirvegnshaqyvedpitgrqsvlvpyeppqvgtefttvlynfmcnsscvggmnrrpiliivtletrdgqvlgrrcfearicACpgRdrkadedsi > 3us2_C interface=181,182,185, spsntdypgphsfdvsfqqsstksatwtystelkklycqiaktcpiqikvmtpppqgavirampvykkaehvtevvkrcpnhelsrefnegqiappshlirvegnshaqyvedpitgrqsvlvpyeppqvgtefttvlynfmcnsscvggmnrrpiliivtletrdgqvlgrrcfearicACpgRdrkadeds > 3us2_D interface=169,170,173, dypgphsfdvsfqtwtystelkklycqiaktcpiqikvmtpppqgavirampvykkaehvtevvkrcpnhelsrefnegqiappshlirvegnshaqyvedpitgrqsvlvpyeppqvgtefttvlynfmcnsscvggmnrrpiliivtletrdgqvlgrrcfearicACpgRdrkadedsi
interface signature	ACR/ACR/ACR/ACR

Estimated binding specificities ?

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# IC=7.873 IC/col=0.606 n_of_columns=13

specificity:

A |   0  69   0   0  24  24  24  24  24   0  69   0   0
C |  96   8   8   0  24  24  24  24  24  96   8   8   0
G |   0   8   8  96  24  24  24  24  24   0   8   8  96
T |   0  11  80   0  24  24  24  24  24   0  11  80   0

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updated Tue Jul 29 23:14:32 2025