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structure nameEXPANDING LAGALIDADG ENDONUCLEASE SCAFFOLD DIVERSITY BY RAPIDLY SURVEYING EVOLUTIONARY SEQUENCE SPACE
(Intron-encoded DNA endonuclease I-HjeMI)
referenceScharenberg et al. 'Nucleic 40 4954 2012
sourceTrichoderma reesei
experimentX-ray (resolution=3.00, R-factor=0.285)
structural superfamilyHoming endonucleases;
sequence familyLAGLIDADG endonuclease;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureYSTKYTEERRMRRCSYLNYISDAYTCRKTR

Estimated binding specificities ?

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# IC=15.274 IC/col=0.804 n_of_columns=19 specificity:   
A |   3  96   0   3  96   0   0   6  24  24  24   0   0   0   0  24  12  71  86
C |   3   0   0   3   0   0   0  12  24  24  24   0  96   0   0  24  10   7   3
G |  24   0  96  87   0  96  96  20  24  24  24   0   0   0  80  24   6   9   4
T |  66   0   0   3   0   0   0  58  24  24  24  96   0  96  16  24  68   9   3
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Dendrogram of similar interfaces ?

matrix format



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updated Mon Jun 29 17:15:09 2026