3x1l_ABCDEFGH : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF THE CRISPR-CAS RNA SILENCING CMR COMPLEX BOUND TO A TARGET ANALOG
reference	Numata et al. Mol.Cell 58 418 2015
source	ARCHAEOGLOBUS FULGIDUS DSM 4304 / PYROCOCCUS FURIOSUS DSM 3638
experiment	X-ray (resolution=2.10, R-factor=?)
reference complex	3x1l_D
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 3x1l_A interface=494, dptllrikivpvqpfiansrkqldlwasshllsmlmykalevivdkfgpehviypslrdqpfflkfylgenigdeilvanlpnkalaivsgkeaekieeeikkrirdfllqlyreavdwavengvvkvdrsekdsmlkeaylkivreyftvsitwvslsekediyqvtenaglsrvleriaiypllvkildslgerkvteerfekseqlkgwkchvcgenlaifgdmydhdnlkslwldeeplcpmclikryypvwirsktgqkirfesvvdvallyknwrkifdekygkdlvskarevsedfvkdnmlvdsdlyysstweseekvkevvdflnaaykeignppkyyailvmdgdtpqvhvaisqalanfsirevrsvvkdeglliyaggddvlailpvdkalevaykirkefgksfklsagilivhykhplydalekardllnnkaknvpgkdtlaigllkrsgsyyislvgwelirvfynselrkkllegkRfiyhvlrevdtwpkvgidemlkfevirhirnkeetkelrekiygeikdllehvrgnnevekvrglftflkiitdaevfp > 3x1l_B interface=155,160, mievtftpydvllfresrpfdagsesvarsiiplpqtvagairtllfykglkncvgvgeeepeftlvgiaigtriyplpfniiksekfykvvnpgrflgklilppkgkyksgyvtesilekylkgelkeveenkviriekekrigiklsrekkvVeegmLytveflriekiyawiedpgcgikdilssyefltlggesrvafvevddktpdifnrelgstkkalfyfstptigkvgeivqelekrlnakiddyllvssrptaisgwdmhekkpkgtkfaippgsvlfvefkeevevppyiklgklkklgyglalggiwe > 3x1l_C interface=25,26,242,251,256,257, kavvfglysitpvhagsgaelsviDLpiqrerhtgfpviwgqslkgvlrsrfrqleldekievsqkwkwkektkevlkekadefikkveerkrdpllteivfgpatdgasehagavsvgdakillfpvrsakgvfafvtspiviqrlkedfelvsvelsnnetiagnalilngenkviledivlkvksdsnvienlvevlktlfgdnffgkpiesikeriaivsddvfksftrfsteivarVridaekgtVarggLWyeeflpsdtlmysliavgspkkenlpkevdntqkivnvlkvtfnnaflqiggdetvgkgfvkvra > 3x1l_D interface=31,32,116,252,260,265,266, mfdmfekavvfglysitpvhagsgaelsviDLpiqrerhtgfpviwgqslkgvlrsrfrqleldekieveqkwkwkektkevlkekadefikkveerkrdpllteivfgpatdgaSehagavsvgdakillfpvrsakgvfafvtspiviqrlkedfelvseiendielkkvelsnnetiagnalilngenkviledivlkvksvienlvevlktlfgdnffgkikeriaivsddvfksftrfsteivarvRidaekgtVarggLWyeeflpsdtlmysliavgspkklpkevdntqkivnvlkvtfnnaflqiggdetvgkgfvkvragv > 3x1l_E interface=29,30,113,114,264,265, dmfekavvfglysitpvhagsgaelsviDLpiqrerhtgfpviwgqslkgvlrsrfrqleldekievsqkwkwkektkevlkekadefikkveerkrdpllteivfgpatdgASehagavsvgdakillfpvrsakgvfafvtspiviqrlkedfelvseienvelsnnetiagnalilngenkviledivlkvksdsnvienlvevlktlfgdnffgkpiesikeriaivsddvfksftrfsteivarvridaekgtvarggLWyeeflpsdtlmysliavgspkklpkevdntqkivnvlkvtfnnaflqiggdetvgkgfvkvragv > 3x1l_F interface=38, ireieqerasfafkvvsdikdkysqnkkvqgkyssyaEkaptiilnnglgatlafflskliddvdyksinpesfgnaeniayaflykhlstwlaegngkdsafsgltngedplkyimektaidvaisteealsilnwikkfakaml > 3x1l_G interface=36,39,40, direieqerasfafkvvsdikdkysqnkkvqgkysSyaEKaptiilnnglgatlafflsklekpiddvdyksinpesfgnaeniayaflykhlstwlaegngkdsafsgltngedplkyimektaidvaisteealsilnwikkfakamlee > 3x1l_H interface=116,117,215,244,245, vvvkypvnselanyaekfwkkelaiynlslilnkmtpfvkrrsesyksslsavkeifknvddfqnflnsvlrrsldeyrvffenyerlfnsfsskifsmrtksrlvvglgdesvyETsirlhrnygvpyipgsalkgvakhyafsilarengdeilriyesvkedlkedyyltaaviqelfekkfdelgairntrveigdtvisvgdivkifgtQkeegsviffdafptpeqlkdkpnleldiMIffltvpagveftfavasrdlddlaekaekllkealkkfgvgaktslgygrfd
interface signature	R/VL/DLVVLW/DLSRVLW/DLASLW/E/SEK/ETQMI

Estimated binding specificities ?

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# IC=19.233 IC/col=0.874 n_of_columns=22

specificity:

A |   0  24  24   8  96  96   6   0  24   0   0   0   0  57  12  96   0   0  24  24  96  96
C |  96  24  24  76   0   0   6   0  24  96  96   0  96  12   8   0  96   0  24  24   0   0
G |   0  24  24   6   0   0  76  96  24   0   0  96   0  12  12   0   0   0  24  24   0   0
T |   0  24  24   6   0   0   8   0  24   0   0   0   0  15  64   0   0  96  24  24   0   0

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updated Wed Jun 24 19:41:20 2026