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structure nameSTRUCTURE OF MOUSE DNMT1 (731-1602) BOUND TO HEMIMETHYLATED CPG DNA
(DNA cytosine-5-methyltransferase 1)
referencePatel et al. Science 335 709 2012
sourceMus musculus
experimentX-ray (resolution=2.60, R-factor=0.198)
structural superfamilyS-adenosyl-L-methionine-dependent methyltransferases;
sequence familyBAH domain; C5 cytosinespecific DNA methylase;
redundant complexes3pt6_B 6w8v_B
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKMRFNHNEMKQ

Estimated binding specificities ?

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# IC=3.101 IC/col=0.620 n_of_columns=5 specificity:   
A |  54  24   0   0  13
C |  13  24   0   0  16
G |  13  24  96  96  54
T |  16  24   0   0  13
scan!

Dendrogram of similar interfaces ?

matrix format
  
  KG--------------------MG--RGFGNG------------HGNA------------EGMC--KGQG----   L           +--------------------4da4_B    
                                                                                           ! 
  ------------------SG------------------------------------ECRG----AT--------               !               +----5ciy_A    
                                                                                           !       +-------3 
  ------------------VGQG--------------------------FGNGSGEG----SCAGNG--------   L     +-----7       !       +----4dkj_A    
                                                                                     !     !    +--4 
  ------------CC------NAVGNGPG------ECNCVCRC------------------------------RC         !     !    !  !            +6kdb_D    
                                                                                     !     !    !  !          +-1 
  --------------------IAVG--PG----------------------------------------------   L     !     +----6  +----------2 +6w8b_A    
                                                                                   +-8          !             ! 
  --------------NT------VT----------------------------------------------LG--       ! !          !             +-6pa7_K    
                                                                                   ! !          ! 
  ------------------------------------------SG------------------------------   L   ! !          +---------------3ubt_A    
                                                                                 --9 ! 
  ----------NAYA----------YG------------------------------------------------   L   ! !           +--------------2ih2_D    
                                                                                   ! +-----------5 
  ----------NA------FA--------KG--------------------------------------------   L   !             +--------------5hr4_C    
                                                                                   ! 
  --FTDTITVTAT--KAAA------------WGLG----------------------------------------   L   +----------------------------3zh2_C    
                                                                                 

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updated Tue Dec 19 08:41:25 2023