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structure nameCRYSTAL STRUCTURE OF KAISO ZINC FINGER DNA BINDING DOMAIN IN COMPLEX WITH KAISO BINDING SITE DNA
(Transcriptional regulator Kaiso)
referenceMartinez-Yamout et al. Proc.Natl.Acad.Sci.USA 109 15229 2012
sourceHomo sapiens
experimentX-ray (resolution=2.40, R-factor=0.223)
structural superfamilybeta-beta-alpha zinc fingers;
sequence familyZinc finger, C2H2 type;
redundant complexes4f6n 2lt7
reference complex2lt7_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureTSRLEYNYQR

Estimated binding specificities ?

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# IC=8.338 IC/col=1.042 n_of_columns=8 specificity:   
A |  13   0  13   0   0   0  14  83
C |  16  96  82   0   0  96  82   0
G |  13   0   0   0  96   0   0  13
T |  54   0   1  96   0   0   0   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  ------TTSGRG--LT--ETYC----NTYGQG----RG   L            +--------4f6m_A    
                                                    +---5 
  ITST--STHTRG--RG----EA--RA--TTTGECRG--   L        !   +--------5v3j_F    
                                                    ! 
  --QA--TTNA--STQAQTATSTNTATTTLAHGTCRG--   L     +--6             +1g2f_F    
                                                 !  !           +-1 
  --KT--STHT----RG--DAQA--RGRGSTDCHGTT--   L     !  !        +--3 +6b0o_A    
                                                 !  !        !  ! 
  ------KGDCRG--QARGATNA----QA--ATHG----   L   +-7  +--------4  +2i13_A    
                                               ! !           ! 
  --EC--SCKGRG----TCYCKA--RGQA----TC----   L   ! !           +---5yeg_A    
                                               ! ! 
  --RGSTDAHARG--RGSTDCHG--TTRG--DAEGRG--   L --8 !               +5kl3_A    
                                               ! +---------------2 
  --KG--WTKA--------HCHG--RGTA--ACNAKG--   L   !                 +1tf6_A    
                                               ! 
  --------------RG--DGEC--RGRGSGDCHA----   L   +-----------------2wbs_A    
                                             

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updated Thu Sep 12 19:13:23 2024