4i3h_AB : 3D-footprint complex

structure name	A THREE-GATE STRUCTURE OF TOPOISOMERASE IV FROM STREPTOCOCCUS PNEUMONIAE
reference	Sanderson et al. 'Nucleic 41 9911 2013
source	STREPTOCOCCUS PNEUMONIAE
experiment	X-ray (resolution=3.70, R-factor=?)
structural superfamily	Type II DNA topoisomerase;
reference complex	8c41_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4i3h_A interface=387,573,633,723, avrkrpgmyigstdgaglhhlvweivdnavdealsdridvtinkdgsltvqdhtveviftilhaggkflhgvgssvvnalsswleveitrdgavykqrfenggkpvttlkkigtapksktgtkvtfmpdatifsttdfkyntiserlnesafllknvtlsltdkrtdeaiefhyengvqdfvsylnedkeiltpvlyfegedngfqvevalqyndgfsdnilsfvnnvrtkdggthetglksaitkvmndyarktgllkekegsdyreglaavlsilvpeehlqfegqtkdklgsplarpvvdgivadkltfflmengelasnlirkaikardareaarkargkltpaqsknpaknelylvegdsaggsakqgrdrkfqailplrgKvintakakmadilkneeintmiytigagvgadfsiedanydkiiimtdadtdgahiqtllltffyrymrplveaghvyialpplykmskgayawdgeleelrlqrykglgemnadqlwettmnpetrtlirvtiedlaraerrvnvlmgdkveprrkwiednvkftleniqnmsledimgerfgrYskyiiqdralpdirdglkpvqrrilysmnkdsntfdksyrksaksvgnimgnfhphgdsSiydamvrmsqnwknreilvemhgnngsmdgdppaamrytearlseiagyllqdiekktvpfawnfddtekeptvlpaafpnllvngstgIsagyatdipphnlaevidaavymidhptakidklmeflpgpdfptgaiiqgrdeikkayetgkgrvvvrskteieklkggkeqiviteipyeinkanlvkkiddvrvnnkvagiaevrdesdrdglriaielkkdantelvlnylfkytdlqinynfnmvaidnftprqvgivpilssyiahrrevilarsrfdkekaekrlhiveglirvisildevialirasenkadakenlkvsydfteeqaeaivtlqlyrltntdvvvlqeeeaelrekiamlaaiigdertmynlmkkelrevkkkfatprlssled > 4i3h_B interface=391,631,721, egldavrkrpgmyigstdgaglhhlvweivdnavdealsgfdridvtinkdgsltvqdhtveviftilhaggkfgvgssvvnalsswleveitrdgavykqrfenggkpvttlkkigtapktgtkvtfmpdatifsttdfkyntiserlnesafllknvtlsltdkrtdeaiefhyengvqdfvsylnedkeiltpvlyfegedngfqvevalqyndgfsdnilsfvnnvrtkdggthetglksaitkvmndyarktgllnlegsdyreglaavlsilvpeehlqfegqtkdklgsplarpvvdgivadkltfflmengelasnlirkaikardareaarkardesgkltpaqsknpaknelylvegdsaggsakqgrdrkfqailplrgKvintakakmadilkneeintmiytigagvgadfsiedanydkiiimtdadtdgahiqtllltffyrymrplveaghvyialpplykmawtdgeleellqrykglgemnadqlwettmnpetrtlirvtiedlaraerrvnvlmgdkveprrkwiednvkftsniqnmsledimgerfgryskyiiqdralpdirdglkpvqrrilysmnkdsntfdksyrksaksvgnimgnfhphgdsSiydamvrmsqnwknreilvemhgnngsmdgdppaamrytearlseiagyllqdiekktvpfawnfddtekeptvlpaafpnllvngstgIsagyatdipphnlaevidaavymidhptakidklmeflpgpdfptgaiiqgrdeikkayetgkgrvvvrskteieklkggkeqiviteipyeinkanlvkkiddvrvnnkvagiaevrdesdrdglriaielkkdantelvlnylfkytdlqinynfnmvaidnftprqvgivpilssyiahrrevilarsrfdkekaekrlhiveglirvisildevialirasenkadakenlkvsydfteeqaeaivtlqlyrltntdvvvlqeeeaelrekiamlaaiigdertmynlmkkelrevkkkfatprlssled
interface signature	KYSI/KSI

Estimated binding specificities ?

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# IC=6.405 IC/col=0.458 n_of_columns=14

specificity:

A |   0   0   8  45  24  24  24  24  24  24   8  24   0   0
C |   0   0  17  17  24  24  24  24  24  24  10  24   0   0
G |   0  96  52  17  24  24  24  24  24  24   0  24   0   0
T |  96   0  19  17  24  24  24  24  24  24  78  24  96  96

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updated Mon Jan 5 09:26:50 2026