4i3h_AB : 3D-footprint complex

structure name	A THREE-GATE STRUCTURE OF TOPOISOMERASE IV FROM STREPTOCOCCUS PNEUMONIAE
reference	Sanderson et al. 'Nucleic 41 9911 2013
source	STREPTOCOCCUS PNEUMONIAE
experiment	X-ray (resolution=3.70, R-factor=?)
structural superfamily	Type II DNA topoisomerase;Ribosomal protein S5 domain 2-like;ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase;
reference complex	4i3h_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4i3h_A interface=387,573,633,723, avrkrpgmyigstdgaglhhlvweivdnavdealsdridvtinkdgsltvqdhtveviftilhaggkflhgvgssvvnalsswleveitrdgavykqrfenggkpvttlkkigtapksktgtkvtfmpdatifsttdfkyntiserlnesafllknvtlsltdkrtdeaiefhyengvqdfvsylnedkeiltpvlyfegedngfqvevalqyndgfsdnilsfvnnvrtkdggthetglksaitkvmndyarktgllkekegsdyreglaavlsilvpeehlqfegqtkdklgsplarpvvdgivadkltfflmengelasnlirkaikardareaarkargkltpaqsknpaknelylvegdsaggsakqgrdrkfqailplrgKvintakakmadilkneeintmiytigagvgadfsiedanydkiiimtdadtdgahiqtllltffyrymrplveaghvyialpplykmskgayawdgeleelrlqrykglgemnadqlwettmnpetrtlirvtiedlaraerrvnvlmgdkveprrkwiednvkftleniqnmsledimgerfgrYskyiiqdralpdirdglkpvqrrilysmnkdsntfdksyrksaksvgnimgnfhphgdsSiydamvrmsqnwknreilvemhgnngsmdgdppaamrytearlseiagyllqdiekktvpfawnfddtekeptvlpaafpnllvngstgIsagyatdipphnlaevidaavymidhptakidklmeflpgpdfptgaiiqgrdeikkayetgkgrvvvrskteieklkggkeqiviteipyeinkanlvkkiddvrvnnkvagiaevrdesdrdglriaielkkdantelvlnylfkytdlqinynfnmvaidnftprqvgivpilssyiahrrevilarsrfdkekaekrlhiveglirvisildevialirasenkadakenlkvsydfteeqaeaivtlqlyrltntdvvvlqeeeaelrekiamlaaiigdertmynlmkkelrevkkkfatprlssled > 4i3h_B interface=391,631,721, egldavrkrpgmyigstdgaglhhlvweivdnavdealsgfdridvtinkdgsltvqdhtveviftilhaggkfgvgssvvnalsswleveitrdgavykqrfenggkpvttlkkigtapktgtkvtfmpdatifsttdfkyntiserlnesafllknvtlsltdkrtdeaiefhyengvqdfvsylnedkeiltpvlyfegedngfqvevalqyndgfsdnilsfvnnvrtkdggthetglksaitkvmndyarktgllnlegsdyreglaavlsilvpeehlqfegqtkdklgsplarpvvdgivadkltfflmengelasnlirkaikardareaarkardesgkltpaqsknpaknelylvegdsaggsakqgrdrkfqailplrgKvintakakmadilkneeintmiytigagvgadfsiedanydkiiimtdadtdgahiqtllltffyrymrplveaghvyialpplykmawtdgeleellqrykglgemnadqlwettmnpetrtlirvtiedlaraerrvnvlmgdkveprrkwiednvkftsniqnmsledimgerfgryskyiiqdralpdirdglkpvqrrilysmnkdsntfdksyrksaksvgnimgnfhphgdsSiydamvrmsqnwknreilvemhgnngsmdgdppaamrytearlseiagyllqdiekktvpfawnfddtekeptvlpaafpnllvngstgIsagyatdipphnlaevidaavymidhptakidklmeflpgpdfptgaiiqgrdeikkayetgkgrvvvrskteieklkggkeqiviteipyeinkanlvkkiddvrvnnkvagiaevrdesdrdglriaielkkdantelvlnylfkytdlqinynfnmvaidnftprqvgivpilssyiahrrevilarsrfdkekaekrlhiveglirvisildevialirasenkadakenlkvsydfteeqaeaivtlqlyrltntdvvvlqeeeaelrekiamlaaiigdertmynlmkkelrevkkkfatprlssled
interface signature	KYSI/KSI

Estimated binding specificities ?

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# IC=5.766 IC/col=0.412 n_of_columns=14

specificity:

A |  96  96  24  54  24  24  24  24  24  24  13  24   0  96
C |   0   0  24  16  24  24  24  24  24  24  16  24  96   0
G |   0   0  24  13  24  24  24  24  24  24  13  24   0   0
T |   0   0  24  13  24  24  24  24  24  24  54  24   0   0

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updated Wed Jul 30 01:25:45 2025