4nw3_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF MLL CXXC DOMAIN IN COMPLEX WITH A CPG DNA (HISTONE-LYSINE N-METHYLTRANSFERASE 2A)
reference	Structure 26 85 2018 X-RAY DIFFRACTION
source	HOMO SAPIENS
experiment	X-ray (resolution=2.82, R-factor=0.221)
sequence family	CXXC zinc finger domain;
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4nw3_A interface=36,37,38, rrsrrcgqcpgcqvpedcgvctncldkpkfggrniKKQcckmrkcqnlqwm
interface signature	KKQ

Estimated binding specificities ?

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# IC=3.142 IC/col=0.786 n_of_columns=4

specificity:

A |  13   0   0  54
C |  13  96   0  13
G |  13   0  96  13
T |  57   0   0  16

scan!

Dendrogram of similar interfaces ?

matrix format

  
  ------KTKGQC--   L                        +4nw3_A    
                                        +---1 
  --NTICKGKGQGKT   L   +----------------2   +2kkf_A    
                       !                ! 
  RT----MAKGQG--   L --4                +---6asb_F    
                       ! 
  RC------KGQG--   L   !              +-----4pzi_A    
                       +--------------3 
  --------RGQG--   L                  +-----5w9q_B

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updated Thu Sep 12 19:53:05 2024