interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF THE METAL-FREE (REPRESSOR) FORM OF E. COLI CUER, A COPPER EFFLUX REGULATOR, BOUND TO COPA PROMOTER DNA
(HTH-type transcriptional regulator CueR)
referenceCanalizo-Hernandez et al. Science 349 877 2015
sourceEscherichia coli DH5[alpha] / Escherichia coli DH5[alpha]
experimentX-ray (resolution=2.10, R-factor=0.214)
structural superfamilyPutative DNA-binding domain;
sequence familyMerR, DNA binding; MerR family regulatory protein;
redundant complexes6xh7 6xh8 4wlw 7c17 6ldi
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKRFY

Estimated binding specificities ?

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# IC=5.048 IC/col=0.631 n_of_columns=8 specificity:   
A |   7  24  24   7   0   0  73   0
C |  73  24  24   7  96  96   9   7
G |   7  24  24  16   0   0   7  81
T |   9  24  24  66   0   0   7   8
scan!

Dendrogram of similar interfaces ?

matrix format
  
  RGRTYTKT   L                     +7tea_B    
                 +-----------------1 
  RGHTHCYG   L   !                 +1r8d_B    
               --3 
  RART----       !            +----4r24_B    
                 +------------2 
  RCRT----                    +----7tec_A    
               

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updated Sat Aug 2 07:20:47 2025