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legend  pdf

structure nameCRYSTAL STRUCTURE OF T. AQUATICUS TRANSCRIPTION INITIATION COMPLEX CONTAINING BUBBLE PROMOTER AND RNA
(RNA POLYMERASE SIGMA FACTOR SIGA)
referenceDarst et al. Elife 4 ? 2015
sourceTHERMUS AQUATICUS
experimentX-ray (resolution=4.00, R-factor=0.282)
structural superfamilySigma2 domain of RNA polymerase sigma factors;Sigma3 and sigma4 domains of RNA polymerase sigma factors;
sequence familySigma70 region 3; Sigma70 region 2; Sigma70, region 4; Sigma70 factor, region 12;
redundant complexes4xlr 4xls 4xlp 4xlq
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureDVRLHLLENRLYFFERFKSTYTWWRQNRRVHEIRRAIDESFLTRERRQ

Estimated binding specificities ?

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# IC=26.235 IC/col=0.772 n_of_columns=34 specificity:   
A |   0   0   0   0  96   0  73  24  24  24  24  24  24  24  24  24  24  24  24   0   7   0   0   0   0  96   0  73   0   0   0   0   0  73
C |  96   0   0   0   0  96   9  24  24  24  24  24  24  24  24  24  24  24  24   0   7   0   0  96   0   0   0   9  96   0   0   0   0   9
G |   0   0   0  96   0   0   7  24  24  24  24  24  24  24  24  24  24  24  24   0  73   0  96   0   0   0   0   7   0   0  96  96  96   7
T |   0  96  96   0   0   0   7  24  24  24  24  24  24  24  24  24  24  24  24  96   9  96   0   0  96   0  96   7   0  96   0   0   0   7
scan!

Dendrogram of similar interfaces ?

matrix format
  
  DGVGRGLGHG--LTLTET--NTRGLT------YA--------FG--FAEA--RAFAKTSTTAYATCWTWTRCQTNARG----RT--VGHT--ECIT----RARA--AT--------IG--DGEG--SG--FG----LT--TTRGECRCRTQC--------   L                                +4xln_F    
                                                                                                                                                                                               +------2 
  DGVGRGLG--IGLT--ET--NTRGLT------------------KTFAEA--RAFA--SATAYATA--WTRA--------------------------------------------IG------DG----FG----------------------------                             !      +6kqf_F    
                                                                                                                                                                                             +-7 
  DGVGRGLG----LT--ET--NTRGLT------------RC------FADA--KAYA--SCTAYATCWTWT--QT------------VTHT--EA------RCRCEC--EGIASAQAIC----EGDGSG--FG--------TTRGECRTRCQT--------   L                       ! !      +6edt_F    
                                                                                                                                                                                             ! +------1 
  ------------LT--ET--NTRTLT--------------------FADA--KAYAKTSTTAYATCWTWC--QCTARG--------VTHT--EC------------------------------------------LG--TTRGECRCRTQT--------   L                       !        +5vi8_F    
                                                                                                                                                                                   +---------8 
  --------------------NTRTLT----------------LA--FADA--RA--RTSCTAYATCWTWC--QCEARG--------ITHG--KC------------------------------------------------RGET--RC----------   L             !         !       +6omf_F    
                                                                                                                                                                                   !         !   +---3 
  --------------------NTRTLT--------------------FADA--------STTCYATTWTWG--QA--RG----------------------------------------------------------------RCEC----QT--------                 !         !   !   +6wmr_Z    
                                                                                                                                                                               +---9         +---6 
  ----------------------PGLGRAHCLG----VTRA------------QATA----TAYA--QARC----LC----LT--DTRT--RT------------------LG----WARGET----DAIA------------------------------   L         !   !             !  +-6pmi_F    
                                                                                                                                                                               !   !             +--5 
  --------------------NTRGLT----------NCRT--FT--FAEA--RAYA--STTAYATTWTWT--QTTART----------HG--EA--NTNT--RT------------IG------------FG----LT--TTRGECRTRTQT--------   L      +-10   !                +-6xl5_F    
                                                                                                                                                                            !  !   ! 
  ------------------AT--RT----------VA--RT----------RA------STTAYATAWA--RAQTTARGIA--------HT--EA----------------------IG----------LGFG--------TT--ECRT--QT--------   L      !  !   +------------------7f75_F    
                                                                                                                                                                            !  !  
  ----------------------DGQG--------LG--MARTPG--FTRT----TTNTKGAGWTYGRT----------------------------------------------------------------PCFCYG--------TGMGSG----RGQC   L   +-12  +----------------------5zx2_F    
                                                                                                                                                                         !  !  
  ----------------------------------------------------------------------------------------------------------------------------------RG----------------------------       !  !  +------------------------6jcy_F    
                                                                                                                                                                         !  +-11  
  ----------------------------------------------------------------------------------------------------------------------------------------LT--TTRGETRC--RCQC------   L -13     !                       +6ido_B    
                                                                                                                                                                         !     +-----------------------4 
  ----------------------------------------------------------------------------------------------------------------------------------------LG--------TAKGTA--HTRG--   L   !                             +6jhe_A    
                                                                                                                                                                         !  
  ----------------------------------------------------------------------------------------------------------------------------------------LTETTTRAECRCRCQC--------   L   +--------------------------3n97_A    
                                                                                                                                                                       

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updated Thu Sep 12 20:13:41 2024