4yis_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF LAGLIDADG MEGANUCLEASE I-CPAMI BOUND TO UNCLEAVED DNA (Meganuclease I-CpaMI)
reference	Hallinan et al. Structure 24 862 2016
source	Cryphonectria parasitica
experiment	X-ray (resolution=2.89, R-factor=0.220)
structural superfamily	Homing endonucleases;
sequence family	LAGLIDADG endonuclease;
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4yis_A interface=16,18,20,22,26,27,32,34,36,62,64,70,72,74,175,177,179,181,183,185,186,191,193,195,225,232,234,236, sfnpwfltgfsdaecSfSiLiQansKYstgwRiKpVfaiglhkkdnellkriqsylgvgkiHiHgkdsiQfRiDspkeleviinhfenyplvtakqadytlfkkaldviknkehlsqkgllklvgikaslnlglngslkeafpnweelqidrpsyvnkgipdpnwisgfasgdsSfNvKiSnSpTSllnkRvQlRfgiglnirekaliqylvayfdlsdnlkniYfdlnsaRfEvVkfsditdkiipffdkysiqgkksqdyqnfkevadiiksknhltsegfqeildikasmnk
interface signature	SSLQKYRKVHHQRDSNKSSTSRQRYREV

Estimated binding specificities ?

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# IC=20.002 IC/col=0.909 n_of_columns=22

specificity:

A |  84   0   0   0   0   0   0   0  24  24  24  24  24  12   0   0   0   0   0   0  12  96
C |   0   0   0   0  96  96   0   0  24  24  24  24  24  12   0   0   0   0   0  96   0   0
G |  12   0  96  96   0   0  24   0  24  24  24  24  24  12  96   0  12  96  96   0   0   0
T |   0  96   0   0   0   0  72  96  24  24  24  24  24  60   0  96  84   0   0   0  84   0

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Dendrogram of similar interfaces ?

matrix format

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updated Sun Aug 3 08:43:07 2025