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structure nameCRYSTAL STRUCTURE OF LAGLIDADG MEGANUCLEASE I-CPAMI BOUND TO UNCLEAVED DNA
(Meganuclease I-CpaMI)
referenceHallinan et al. Structure 24 862 2016
sourceCryphonectria parasitica
experimentX-ray (resolution=2.89, R-factor=0.220)
structural superfamilyHoming endonucleases;
sequence familyLAGLIDADG endonuclease;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSSLQKYRKVHHQRDSNKSSTSRQRYREV

Estimated binding specificities ?

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# IC=19.788 IC/col=0.899 n_of_columns=22 specificity:   
A |   0  85   0   0   0  85  96   0  64  24  24  24  24  24  96  74   0   0   0   0  96   0
C |  11   1   0  96  96  11   0  96  10  24  24  24  24  24   0  22   0   0  96  96   0  11
G |   0   0  96   0   0   0   0   0  10  24  24  24  24  24   0   0  96  96   0   0   0   0
T |  85  10   0   0   0   0   0   0  12  24  24  24  24  24   0   0   0   0   0   0   0  85
scan!

Dendrogram of similar interfaces ?

matrix format



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updated Sat Jan 10 07:39:08 2026