interface graph thumbnail
legend  pdf

structure nameSTRUCTURAL BASIS OF ASYMMETRIC DNA METHYLATION AND ATP-TRIGGERED LONG- RANGE DIFFUSION BY ECOP15I
(RESTRICTION ENDONUCLEASE ECOP15I, MODIFICATION SUBUNIT)
referenceAggarwal et al. 'Nat 6 7363 2015
sourceESCHERICHIA COLI
experimentX-ray (resolution=2.60, R-factor=0.221)
structural superfamilyS-adenosyl-L-methionine-dependent methyltransferases;
sequence familyDNA methylase;
multimeric complexes4zcf_ABC
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureDYTKDTDNNEDRNK

Estimated binding specificities ?

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# IC=7.099 IC/col=1.014 n_of_columns=7 specificity:   
A |   0  54   0   0  96   0  13
C |  96  13   0  96   0   0  16
G |   0  13  96   0   0  96  13
T |   0  16   0   0   0   0  54
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: ECOP15I
CAGCAGPubMed4zcf_B(8.50e-10), 4zcf_ABC(3.65e-09)
CTGATGPubMed4zcf_B(6.90e-05), 4zcf_ABC(1.66e-04)
CATCAGPubMed4zcf_B(6.90e-05), 4zcf_ABC(1.66e-04)
CTGCTGPubMed4zcf_B(8.50e-10), 4zcf_ABC(3.65e-09)

Dendrogram of similar interfaces ?

matrix format
  
  DAYA--TAKTDA----------------TCDTNGNG----EA--RTNAKA   L            +--------------------4zcf_B    
                                                             +------2 
  DA------------FT------YTHTMCPCNCFTKTTCRTEA----TAKA   L     !      +--------------------6pbd_A    
                                                           +-3 
  ------NT------------------------------------------       ! !                         +-6pa7_K    
                                                         --4 +-------------------------1 
  ----CC----------ECNCVC------------------RCRC--RC--       !                           +-6kdb_D    
                                                           ! 
  NAYA--------KT------------------------------------   L   +----------------------------2ih2_D

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updated Fri Sep 13 19:05:12 2024