5btc_ABCD : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF A TOPOISOMERASE II COMPLEX
reference	Williamson et al. Proc.Natl.Acad.Sci.USA 113 1706 2016
experiment	X-ray (resolution=2.55, R-factor=?)
structural superfamily	Type II DNA topoisomerase;
reference complex	5bs8_A 5bs8_D
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5btc_A interface=76,77,114,166, iepvdieqemqrsyidyamsvivgralpevrdglkpvhrrvlyamfdsgfrpdrshaksarsvaetmgnyhphgdSSiydslvrmaqpwslryplvdgqgnfgspgndppaamRtearltplamemlreideetvdfipnydgrvqeptvlpsrfpnllangsggIavgmatnipphnlreladavfwalenhdadeeetlaavmgrvkgpdfptaglivgsqgtadayktgrgsirmrgvveveedsrgrtslvitelpyqvnhdnfitsiaeqvrdgklagisniedqssdrvglrivieikrdavakvvinnlykhtqlqtsfganmlaivdgvprtlrldqliryyvdhqldvivrrttyrlrkanerahilrglvkaldaldevialirasetvdiaraglielldideiqaqaildmqlrrlaalerqriiddlakieaeiadledilakperqrgivrdelaeivdrhgddrrtriiai > 5btc_B interface=54, alvrrkglpgkladcrstdprkselyvvegdsaggsaksgrdsmfqailplrgKiinvekaridrvlkntevqaiitalgtgihdefdigklryhkivlmadadvdgqhistllltllfrfmrplienghvflaqpplyklkwqrsdpefaysdrerdglleaglkagkkinkedgiqrykglgemdakelwettmdpsvrvlrqvtlddaaaadelfsilmgedvdarrsfitrnakdvrfldv > 5btc_C interface=17,35,76,77,114,166, iepvdieqemqrsyidYamsvivgralpevrdglKpvhrrvlyamfdsgfrpdrshaksarsvaetmgnyhphgdSSiydslvrmaqpwslryplvdgqgnfgspgndppaamRtearltplamemlreideetvdfipnydgrvqeptvlpsrfpnllangsggIavgmatnipphnlreladavfwalenhdadeeetlaavmgrvkgpdfptaglivgsqgtadayktgrgsirmrgvveveedsrgrtslvitelpyqvnhdnfitsiaeqvrdgklagisniedqssdrvglrivieikrdavakvvinnlykhtqlqtsfganmlaivdgvprtlrldqliryyvdhqldvivrrttyrlrkanerahilrglvkaldaldevialirasetvdiaraglielldideiqaqaildmqlrrlaalerqriiddlakieaeiadledilakperqrgivrdelaeivdrhgddrrtriiai > 5btc_D interface=56, nalvrrksglpgkladcrstdprkselyvvegdsaggsaksgrdsmfqailplrgKiinvekaridrvlkntevqaiitalgtgihdefdigklryhkivlmadadvdgqhistllltllfrfmrplienghvflaqpplyklkwqrsdpefaysdrerdglleaglkagkkinkedgiqrykglgemdakelwettmdpsvrvlrqvtlddaaaadelfsilmgedvdarrsfitrnakdvrfldv
interface signature	SSRI/K/YKSSRI/K

Estimated binding specificities ?

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# IC=7.366 IC/col=0.526 n_of_columns=14

specificity:

A |   0   0  24  66   9  24  24  24  15  69   6  24   0  96
C |   0   0  24   9  12  24  24  24   9  12   6  24  96   0
G |   0  96  24   9  15  24  24  24  15   9  12  24   0   0
T |  96   0  24  12  60  24  24  24  57   6  72  24   0   0

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updated Sat Dec 14 00:40:40 2024