interface graph thumbnail
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structure nameSTRUCTURE OF HOXB13-DNA(TCG) COMPLEX
(Homeobox protein Hox-B13)
referenceMorgunova et al. Elife 7 ? 2018
sourceHomo sapiens
experimentX-ray (resolution=3.20, R-factor=0.219)
structural superfamilyHomeodomain-like;
sequence familyHomeobox domain;
multimeric complexes5edn_AJ 5edn_BG
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKRIQN

Estimated binding specificities ?

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# IC=5.379 IC/col=0.768 n_of_columns=7 specificity:   
A |   9  24   9   0  96  96  67
C |   9  24   9   0   0   0  11
G |   9  24  69   0   0   0   9
T |  69  24   9  96   0   0   9
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Dendrogram of similar interfaces ?

matrix format
  
  ----RA------------------------IAQTNAMC----   L                     +------------1puf_A    
                                                                     !  
  KA--RT------------------------ICQTNA------   L                     !              +5edn_J    
                                                                     !            +-1 
  ----RA----------------RT------ITQCNA------   L                 +--15          +-2 +5eea_B    
                                                                 !   !          ! ! 
  KG--RT------------------------IAQCNAYA--RT   L                 !   !   +------9 +1nk2_P    
                                                                 !   !   !      ! 
  ----RT------------------------ITQCNAMC----   L                 !   +--12      +-2r5y_A    
                                                                 !       !  
  ----RT------------------------IAQTNA----KT   L                 !       !        +4rdu_A    
                                                              +-18       +--------3 
  ----RT------------------------IAQTNASG----   L              !  !                +5zfz_A    
                                                              !  !  
  RT--RT------------------------VAQTNA------   L              !  !                +3lnq_A    
                                                              !  !    +-----------4 
  RT--RT------------------------IAKGNA------   L              !  !    !           +6m3d_C    
                                                              !  +---14  
  ----RT----------------------KTIAQCNA----RT   L              !       !            +1ig7_A    
                                                         +---20       !          +-5 
  ----RA------------------------ITQTNAMG----   L         !    !       +----------7 +5zjt_E    
                                                         !    !                  ! 
  ----RT------------------------ITQCNAACRG--   L         !    !                  +6a8r_A    
                                                         !    !  
  RA--RT------------------------VTKGNA--KA--   L         !    !                +2lkx_A    
                                                         !    !      +---------6 
  RT--RT----------------------QTVAQTNA------   L         !    !      !         +3a01_F    
                                                         !    +-----13  
  ----RT--------------------------KGNA------   L      +-22           !       +--2hos_A    
                                                      !  !           +------10  
  ----------FAWTQANT------------------------   L      !  !                   +--6wq2_b    
                                                      !  !  
  RAYART------------------------VTQTNAMTKTRT   L      !  !      +----------------1jgg_B    
                                                      !  !  +--17  
  ----RA------------------------IA--NA------          !  !  !   !             +--4xrs_G    
                                                      !  !  !   +------------11  
  ----RT----------------------FTYAQTNAATRG--   L   +-23  !  !                 +--6ryd_F    
                                                   !  !  +-21  
  ----RT------------------------IAKGNA------   L   !  !     !                   +2hdd_A    
                                                   !  !     !     +-------------8 
  ----NGRGTG--------LG----LCRG--------------       !  !     +----16             +4ew0_A    
                                                 -24  !           !  
  ------------------------------IA--NA------       !  !           +--------------4qtr_D    
                                                   !  !  
  ----RT----------------------YANC--NAKG----   L   !  +-----------------------4j19_B    
                                                   !  
  ----RG------------------------VA--NAQA----   L   !        +-----------------3l1p_A    
                                                   +-------19  
  ----RT--------------STVC----KGDCRG--------   L            +-----------------1w0t_A    
                                                 

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updated Thu Dec 22 21:24:28 2022