5gzb_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF TRANSCRIPTION FACTOR TEAD4 IN COMPLEX WITH M-CAT DNA (Transcriptional enhancer factor TEF-3)
reference	Zhou et al. Oncogene 36 4362 2017
source	Homo sapiens
experiment	X-ray (resolution=2.70, R-factor=0.232)
structural superfamily	Homeodomain-like;
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5gzb_A interface=33,54,55,58,59,62,63,66, vwspdieqsfqealaiyppcgrrkiilsdegkMygrneliaryiklrtgktrtRKqvSShiQVlaRrkareiqaklkdqaakdkalqsmaa
interface signature	MRKSSQVR

Estimated binding specificities ?

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# IC=6.350 IC/col=0.907 n_of_columns=7

specificity:

A |  17  61   0   0  69  96   0
C |  17  17   0   0  11   0   0
G |  52  10  96  96   8   0   0
T |  10   8   0   0   8   0  96

scan!

Dendrogram of similar interfaces ?

matrix format

  
  ----RGKG--SGSAQAVCRT--   L                    +-----5gzb_A    
                                      +---------4 
  --NGRGKG--SGSAQAVC----   L          !         +-----5no6_N    
                               +------7 
  ------------IAQCNAMC--   L   !      !        +------4uus_E    
                               !      +--------5 
  ------VT--KGDCRGTA----   L   !               +------1w0u_A    
                             --8 
  ------------NT--NA--RG   L   !                  +---1b8i_B    
                               !          +-------3 
  ----STVTMCKGDCRGTA----   L   !          !       !  +1iv6_A    
                               !          !       +--1 
  ------------ICQTNA----   L   +----------6          +5edn_J    
                                          ! 
  ------------NCSTNARG--   L              !         +-1k61_B    
                                          +---------2 
  RA--------KAITQTNAMC--   L                        +-1ahd_P

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updated Sun Aug 3 09:16:59 2025