5hr4_C : 3D-footprint complex

structure name	STRUCTURE OF TYPE IIL RESTRICTION-MODIFICATION ENZYME MMEI IN COMPLEX WITH DNA HAS IMPLICATIONS FOR ENGINEERING OF NEW SPECIFICITIES (MMEI)
reference	Callahan et al. 'Plos 14 e1002442 2016
source	METHYLOPHILUS METHYLOTROPHUS
experiment	X-ray (resolution=2.60, R-factor=0.216)
structural superfamily	S-adenosyl-L-methionine-dependent methyltransferases;
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5hr4_C interface=158,325,328,331,332,333,414,422,423,424,486,489,567,569,570,581,582,595,596,617,649,650,652,654, pqdpinikaaermgklhdtlklvgyeghalelylvrllfclfaedttifekslfqeyietktledgsdlahhintlfyvlntpeqkrlknldehlaafpyingklfeeplppaqfdkamrealldlcsldwsrispaifgslfqsimdakkrrnlgaHytseanilklikplfldelwvefekvknnknkllafhkklrgltffdpacgcgnflvityrelrlleievlrglhrggqqvldiehliqinvdqffgieieefpaqiaqvalwltdhqmnmkisdefgnyfariplkstphilnanalqidwndvleakkccfilgNppFvgKSKqtpgqkadllsvfgnlksasdldlvaawypkaahyiqtnanircafvstnsitqgeqvsllwplllslgikinfahrtfsWtneasgvAAVhcviigfglkdsdekiiyeyesingeplaikakninpylrdgvdviackrqqpisklpsmrYgnKptddgnflftdeeknqfitnepssekyfrrfvggdefinntsrwclwldgadiseiramplvlarikkvqefrlkssAkPTrqsastpmkfFYisqpdtdyllipETssenrqfipigfvdrnvissNatyhipsaeplifgllsstmhncwmrnvggrLEsRyRysaslvyntfpwiqpnekqskaieeaafailkarsnypneslaglydpktmpsellkahqkldkavdsvygfkgpnteiariaflfetyqkmtsl
interface signature	HNFKSKWAAVYKAPTFYETNLERR

Estimated binding specificities ?

contact

# IC=9.634 IC/col=1.204 n_of_columns=8

specificity:

A |   0   0   0   0   0   0  96  12
C |   0   0   0  96   0   0   0  12
G |   0  96   0   0  96  96   0  12
T |  96   0  96   0   0   0   0  60

scan!

Dendrogram of similar interfaces ?

matrix format

  
  --HA------NAFA--KCSGKG--------------WA--AAACVAYCKG--AAPTFTYTECTTNGLCECRGRG--   L            +-------------------5hr4_C    
                                                                                       +------2 
  ----------NAYAYG------KT--------------FAKAKGVA----RG--------------------PTHG   L   +-3      +-------------------2ih2_D    
                                                                                     ! ! 
  YT--YGDGWG--------------STEAMA----------------------------------------------     --4 +--------------------------6ymv_B    
                                                                                     ! 
  ----------------NT----------------------------------------------------------       !                         +-6pa7_K    
                                                                                     +-------------------------1 
  ------------------------------ECNCVC----------------------------------------                                 +-6kdb_D

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updated Fri Sep 13 19:46:16 2024