5j2m_AB : 3D-footprint complex

structure name	HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DNA AND EFDA- TRIPHOSPHATE, A TRANSLOCATION-DEFECTIVE RT INHIBITOR
reference	Sarafianos et al. Proc.Natl.Acad.Sci.USA 113 9274 2016
experiment	X-ray (resolution=2.43, R-factor=?)
structural superfamily	DNA/RNA polymerases;Ribonuclease H-like;
reference complex	7ozw_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5j2m_A interface=94,157,161,183,184,356,448,475, pispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikkkdstkwrklvdfrelnkrtqdfwevqlgIphpaglkkkksvtvldvgdayfsvpldedfrkytaftipsinnetpgiryqynvlpqgwkgsPaifQssmtkilepfrkqnpdiviyqYMddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpivlpekdswtvndicklvgklnwasqiypgikvrqlskllrgtkalteviplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyaRmrgahtndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyqlekepivgaetfyvdgaanRetklgkagyvtnrgrqkvvtltdttnQktelqaiylalqdsglevnivtdsqyalgiiqaqpdqseselvnqiieqlikkekvylawvpahkgiggneqvdklvsagirk > 5j2m_B interface= pietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikkkdstkwrklvdfrelnkrthpaglkkkksvtVldvgdayfsvpldedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepFrkqNpdiviyqymddlyvgsdleigQHrtkieelrqhllrwglelhpdkwtvqpivlpekdswtvndiqklvgklnwasqiypgikvrqlskllrgtkalteviplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqkittesiviwgktpKfklpiqketwetwwteywqatwipewefvntpplvklwyqle
interface signature	IPQYMRRQ/VFNQHK

Estimated binding specificities ?

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# IC=4.434 IC/col=0.261 n_of_columns=17

specificity:

A |  13   0  16  24  24  24  24  24  24  24  24  24  24  24  24   0   0
C |  16   0  54  24  24  24  24  24  24  24  24  24  24  24  24  96   0
G |  54   0  13  24  24  24  24  24  24  24  24  24  24  24  24   0  96
T |  13  96  13  24  24  24  24  24  24  24  24  24  24  24  24   0   0

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updated Mon Jan 5 18:37:48 2026