5j2n_AB : 3D-footprint complex

structure name	HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DNA THAT HAS INCORPORATED EFDA-MP AT THE P-(POST-TRANSLOCATION) SITE AND DTMP AT THE N-(PRE- TRANSLOCATION) SITE
reference	Sarafianos et al. Proc.Natl.Acad.Sci.USA 113 9274 2016
experiment	X-ray (resolution=2.90, R-factor=?)
structural superfamily	DNA/RNA polymerases;Ribonuclease H-like;
reference complex	7ozw_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5j2n_A interface=72,94,115,151,157,183,356,448,475, pispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikkkdstkwRklvdfrelnkrtqdfwevqlgIphpaglkkkksvtvldvgdaYfsvpldedfrkytaftipsinnetpgiryqynvlpQgwkgsPaifqssmtkilepfrkqnpdiviyqYmddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpivlpekdswtvndicklvgklnwasqiypgikvrqlskllrgtkalteviplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyaRmrgahtndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyqlekepivgaetfyvdgaanRetklgkagyvtnrgrqkvvtltdttnQktelqaiylalqdsglevnivtdsqyalgiiqaqpdqseselvnqiieqlikkekvylawvpahkgiggneqvdklvsagirk > 5j2n_B interface= pietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikkkdstkwrklVdfrelnkrtqdiphpaglkkkKsvtvldvgdayfsvpldedfRkytaftipsinnetpgiryqynvlpqgwkgspaifQssmtkIlepfrkqnpdiviyqymddlyvgsdLeigqhrtkieelrqhllrwglmgyelhpdkwtvqpivlpekdswtvndiqklvgklnwasqiypgikvrqlskllrgtkalteviplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqkittesiViwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyqle
interface signature	RIYQPYRRQ/VKRQILV

Estimated binding specificities ?

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# IC=4.092 IC/col=0.241 n_of_columns=17

specificity:

A |   0   0  24  24   0  24  24  24  24  24  24  24  24  24  24  24   0
C |   0  24  24  24  60  24  24  24  24  24  24  24  24  24  24  48   0
G |  96   0  24  24  24  24  24  24  24  24  24  24  24  24  24  12   0
T |   0  72  24  24  12  24  24  24  24  24  24  24  24  24  24  12  96

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updated Thu Jun 25 06:00:17 2026