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legend  pdf

structure nameSTRUCTURAL BASIS FOR ARYL HYDROCARBON RECEPTOR MEDIATED GENE ACTIVATION
(ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR)
referenceSchulte et al. Structure 25 1025 2017
sourceMUS MUSCULUS
experimentX-ray (resolution=3.30, R-factor=0.294)
structural superfamilyHLH, helix-loop-helix DNA-binding domain;
sequence familyHelixloophelix DNAbinding domain;
multimeric complexes5nj8_AB
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureHERR

Estimated binding specificities ?

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# IC=4.354 IC/col=0.871 n_of_columns=5 specificity:   
A |   6   0  96  15   4
C |   6  96   0  49   4
G |   6   0   0  15  84
T |  78   0   0  17   4
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: AHR
GCGTGPubMed5nj8_D(1.35e-04), 5nj8_AB(1.62e-06)
CACGCPubMed5nj8_D(1.35e-04), 5nj8_AB(1.62e-06)
GTGCGTGPubMed5nj8_D(1.01e-03), 5nj8_AB(1.65e-07)

Dendrogram of similar interfaces ?

matrix format
  
  ------HG----ECRGRG   L                +-------------4zpk_A    
                           +------------3 
  ------HG----ETRTRG   L   !            +-------------5v0l_A    
                           ! 
  ------HGSTITETRCRG   L --5                          +4h10_A    
                           !                       +--1 
  KT----HGNT--ECRCRG   L   !     +-----------------2  +1nkp_A    
                           !     !                 ! 
  --RT----NTRGECRCQT       +-----4                 +--2ypa_A    
                                 ! 
  NTNGRTECRGRC------   L         +--------------------6od3_F

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updated Fri Sep 13 20:06:39 2024