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structure nameENGINEERED VARIANT OF I-ONUI MEGANUCLEASE TARGETING THE ANOPHELES AGAP007280 GENE; HARBORS 38 POINT MUTATIONS RELATIVE TO WILD-TYPE I- ONUI
(I-ONUI_E-AG007820)
referenceStoddard et al. 'Nucleic 45 8621 2017
sourceSYNTHETIC CONSTRUCT
experimentX-ray (resolution=2.08, R-factor=0.223)
structural superfamilyHoming endonucleases;
sequence familyLAGLIDADG endonuclease;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSIRRMLESKTNMRSWHNWRQSYLKRLWRT

Estimated binding specificities ?

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# IC=20.326 IC/col=1.016 n_of_columns=20 specificity:   
A |   4   0   0   0   0  96   0   4  24   0   0   0  17   0   0  22   0  85   0   6
C |   6  96  96   0  79   0  96  11  24   0  96   0   6  96  96   4  57   7  96  83
G |   4   0   0   0   1   0   0   6  24   0   0   0   6   0   0   4   0   2   0   4
T |  82   0   0  96  16   0   0  75  24  96   0  96  67   0   0  66  39   2   0   3
scan!

Dendrogram of similar interfaces ?

matrix format



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updated Fri Sep 13 20:26:13 2024