5thg_A : 3D-footprint complex

structure name	ENGINEERED VARIANT OF I-ONUI MEGANUCLEASE TARGETING THE HIV CCR5 GENE; HARBORS 43 POINT MUTATIONS RELATIVE TO WILD-TYPE I-ONUI (I-ONUI_E-HCCR5)
reference	Hallinan et al. 'to ? ? ?
source	SYNTHETIC CONSTRUCT
experiment	X-ray (resolution=3.11, R-factor=0.226)
structural superfamily	Homing endonucleases;
sequence family	LAGLIDADG endonuclease;
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5thg_A interface=18,20,22,24,34,36,40,42,66,70,72,134,172,174,176,186,188,190,192,216,218,225,227,231,290, resinpwiltgftdaegSfMlRiRntnnrsvgyYtSlvfEiTlhnkdksileniqstwkvgtinnRgdgTaRlsvtrfedlkviidhfekyplitqklgdyklfkqafsvmenkehlkengikelvrikakmnWglndelkkafpenierplinknipnlkwlagftsgegTfYvHlakeasgkvYvRlRfIigqhirdknlmnslitylgcgtiQeKnrskgsMlHfivTkfsdindkiipvfqentligvkledfedwckvaklieekkhltesgldeikkiklnmnKgrvf
interface signature	SMRRYSETRTRWTYHYRRIQKMHTK

Estimated binding specificities ?

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# IC=16.374 IC/col=0.862 n_of_columns=19

specificity:

A |   0   0   0   0  96  82  24  13  24  24  24   0   0   0  13   0   0  24  96
C |   0  14  96  96   0   1  24  13  24  24  24   0  96  96   0   0   0  24   0
G |  96  82   0   0   0  13  24  57  24  24  24   0   0   0   0  96  96  24   0
T |   0   0   0   0   0   0  24  13  24  24  24  96   0   0  83   0   0  24   0

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Dendrogram of similar interfaces ?

matrix format

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updated Sat Jan 10 08:55:57 2026