interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF MULTI-DOMAIN RAR-BETA-RXR-ALPHA HETERODIMER ON DNA
(RETINOIC ACID RECEPTOR BETA)
referenceRastinejad et al. 'Nat 8 868 2017
sourceHOMO SAPIENS
experimentX-ray (resolution=3.51, R-factor=0.223)
structural superfamilyNuclear receptor ligand-binding domain;Glucocorticoid receptor-like DNA-binding domain;
sequence familyZinc finger, C4 type two domains; Ligandbinding domain of nuclear hormon;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureEKRR

Estimated binding specificities ?

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# IC=3.582 IC/col=0.716 n_of_columns=5 specificity:   
A |   9   0   7   7  73
C |   7   0   9  73   7
G |  73  96   7   9   7
T |   7   0  73   7   9
scan!

Dendrogram of similar interfaces ?

matrix format
  
  --ECKG--RGRG--   L   +---------------------5uan_B    
                       ! 
  CAECKG--KGRG--   L --4                  +--6l6q_B    
                       !   +--------------1 
  --ECKG--KGRG--   L   !   !              +--2ff0_A    
                       +---3 
  --EAKG--RTRTRT           !            +----4umm_E    
                           +------------2 
  ----KGVT--RG--   L                    +----5emp_A    
                     

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updated Thu Sep 12 22:02:54 2024