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structure nameKAISO (ZBTB33) ZINC FINGER DNA BINDING DOMAIN IN COMPLEX WITH A HEMI CPG-METHYLATED DNA RESEMBLING THE SPECIFIC KAISO BINDING SEQUENCE (KBS)
(Transcriptional regulator Kaiso)
referenceMartinez-Yamout et al. Biochemistry 57 2109 2018
sourceHomo sapiens
experimentX-ray (resolution=2.00, R-factor=0.166)
structural superfamilybeta-beta-alpha zinc fingers;
sequence familyZinc finger, C2H2 type;
redundant complexes5vmu 5vmx 5vmz 5vmv 5vmw 4f6m 4f6n 2lt7
reference complex2lt7_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureTSREYNYQFRY

Estimated binding specificities ?

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# IC=4.339 IC/col=0.542 n_of_columns=8 specificity:   
A |   9  16   0  24   1  24   5  67
C |  11  45  96  24   2  24   3   9
G |   9  16   0  24  92  24  85   9
T |  67  19   0  24   1  24   3  11
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: KAISO
CTGCNAPubMed4f6m_A(2.01e-05), 2lt7_A(1.94e-05)
TCCTGCNAPubMed5vmy_A(6.33e-04), 5vmx_A(1.31e-05), 5vmw_A(1.30e-05), ... (total=5)
TCTCGCGAGAPubMed5vmy_A(1.11e-02), 5vmx_A(1.14e-07), 5vmw_A(1.14e-07)
TNGCAGGAPubMed5vmy_A(6.33e-04), 5vmx_A(1.31e-05), 5vmw_A(1.30e-05), ... (total=5)
NCTGCCAPubMed4f6m_A(1.93e-07), 2lt7_A(1.63e-07)

Dendrogram of similar interfaces ?

matrix format



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updated Thu Sep 12 22:09:13 2024