5xn1_CD : 3D-footprint complex

structure name	HIV-1 REVERSE TRANSCRIPTASE Q151M:DNA:ENTECAVIR-TRIPHOSPHATE TERNARY COMPLEX
reference	Yasutake et al. 'Sci 8 1624 2018
source	HUMAN IMMUNODEFICIENCY VIRUS 1
experiment	X-ray (resolution=2.45, R-factor=?)
structural superfamily	DNA/RNA polymerases;Ribonuclease H-like;
reference complex	7ozw_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5xn1_C interface=22,59,61,72,74,76,92,113,181,182,263,446,473,499, spietvpvklkpgmdgpkvkqWplteekikalveictemekegkiskigpenpyntpvFaIkkkdstkwrkLvDfRelnkrtqdfwevqlgIphpaglkqkksvtvldvgdaYfsvpldkdfrkytaftipsinnetpgiryqynvlpmgwkgspaifqssmtkilepfrkqnpdiviyqYMddlyvgsdleigqhrtkieelrqhllrwgfttpdkkhqkeppflwmgyelhpdkwtvqpivlpekdswtvndiqklvgklNwasqiyagikvrqlskllrgtkaltevvplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmkgahtndvkqlteavqkiatesiviwgktpkfklpiqketweawwteywqatwipewefvntpplvklwyqlekepiigaetfyvdgaanRetklgkagyvtdrgrqkvvpltdttnQktelqaihlalqdsglevnivtdsqYalgiiqaqpdkseselvsqiieqlikkekvylawvpahkgiggneqvdklvs > 5xn1_D interface= pietvpvklkpgmdgpkvkqwPlteekikalveictemekegkiskigpenpyntpvfAiKkkdstkwrklVdFrElnkrtqdfwevqlgiPhpaglkqkksvtvldvgdayFsvpldkdfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqyMDdlyvgsdleigqhrtkieelrqhllrwggyelhpdkwtvqpivlpekdswtvndiqklvgklnwasqiyagikvrqlsklLrgtkaltevvplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmkgahtndvkqlteavqkiatesiviwgktpkfklpiqketweawwteywqatwipewefvntpplvklwy
interface signature	WFILDRIYYMNRQY/PAKVFEPFMDL

Estimated binding specificities ?

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# IC=9.490 IC/col=0.288 n_of_columns=33

specificity:

A |   0   0  11   0  24  24  24  24  24  24  24  24  24  24  24   3  24  11   3  24  24  24  24  24  24  24  24  24  24  24   0   0   7
C |   0  96  11  96  24  24  24  24  24  24  24  24  24  24  24   0  24   0  18  24  24  24  24  24  24  24  24  24  24  24   3   0  55
G |   0   0  56   0  24  24  24  24  24  24  24  24  24  24  24   0  24   4  62  24  24  24  24  24  24  24  24  24  24  24  93  96  18
T |  96   0  18   0  24  24  24  24  24  24  24  24  24  24  24  93  24  81  13  24  24  24  24  24  24  24  24  24  24  24   0   0  16

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updated Mon Jan 5 23:48:44 2026