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structure nameCRYSTAL STRUCTURE OF CTCF ZFS6-11-GB7CSE
(Transcriptional repressor CTCF)
referenceWang et al. 'Cell 27 1365 2017
sourceHomo sapiens
experimentX-ray (resolution=2.96, R-factor=0.269)
structural superfamilybeta-beta-alpha zinc fingers;
sequence familyZinc finger, C2H2 type;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureTRSDQRHMQLLTR

Estimated binding specificities ?

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# IC=13.010 IC/col=0.591 n_of_columns=22 specificity:   
A |   2   0   0  24   6   4  94   0  24  24  24  24  24  24  24  24  24   6   0  68   6   0
C |   0   0  96  24   6   2   0  96  72  24  24  24  24  24  24  24  24  80  96   6   4   4
G |   2  96   0  24  54   4   2   0   0  24  24  24  24  24  24  24  24   6   0  12  84   0
T |  92   0   0  24  30  86   0   0   0  24  24  24  24  24  24  24  24   4   0  10   2  92
scan!

Dendrogram of similar interfaces ?

matrix format
  
  ------TG--RA--SCDC------QGRGHTMG--QG----LGLC--TTRG----------   L                +---------------5yel_A    
                                                                                  ! 
  ------------------------QAATHG----RG--DCNA--TT--RGRTDAAT----   L              +-4               +2i13_A    
                                                                                ! !            +--1 
  ------------------------WCSCVGRG--DC--SGNA----------STHG--RG   L              ! +------------2  +5v3g_A    
                                                                         +------5              ! 
  ------------------------DGYCKGRGTCQA----TC------RA--SCDC----   L       !      !              +--5t0u_A    
                                                                         !      ! 
  ------------------------RA--NC------ATSGDC--KG--DCPTSGSARTKG   L   +---6      !  +-------------2gli_A    
                                                                     !   !      +--3 
  RGSTYGYC--QC--TGSTRAYT--------------------------------------   L   !   !         +-------------3uk3_C    
                                                                   --7   ! 
  --NTSTNAVTQTSTSGKG--RGKG------------------------------------   L   !   +-----------------------6u9q_A    
                                                                     ! 
  ----------RG--SGDC------------------------------------------   L   +---------------------------5k5l_F    
                                                                   

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updated Fri Sep 13 21:02:44 2024