5yx2_AD : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF DNMT3A-DNMT3L IN COMPLEX WITH DNA CONTAINING TWO CPG SITES
reference	Zhang et al. Nature 554 387 2018
source	HOMO SAPIENS
experiment	X-ray (resolution=2.65, R-factor=?)
structural superfamily	S-adenosyl-L-methionine-dependent methyltransferases;
reference complex	6pa7_K
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5yx2_A interface=88,89,90,91,207,209,210,211,256, aekrkpirvlslfdgiatgllvlkdlgiqvdryiasevcedsitvgmvrhqgkimyvgdvrsvtqkhiqewgpfdlviggspcndlsIVNParkglyegtgrlffefyrllhdarpkegddrpffwlfenvvamgvsdkrdisrflesnpvmidakevsaahraryfwgnlpgmnrplastvndklelqeclehgriakfskvrtiTtRSNsikqgkdqhfpvfmnekedilwctemervfgfpvhytdvsnmsrLarqrllgrswsvpvirhlfaplkeyfacv > 5yx2_D interface=88,89,90,91,207,208,209,210,211,256, aekrkpirvlslfdgiatgllvlkdlgiqvdryiasevcedsitvgmvrhqgkimyvgdvrsvtqkhiqewgpfdlviggspcndlsIVNParkglyegtgrlffefyrllhdarpkegddrpffwlfenvvamgvsdkrdisrflesnpvmidakevsaahraryfwgnlpgmnrplastvndklelqeclehgriakfskvrtiTTRSNsikqgkdqhfpvfmnekedilwctemervfgfpvhytdvsnmsrLarqrllgrswsvpvirhlfaplkeyfacv
interface signature	IVNPTRSNL/IVNPTTRSNL

Estimated binding specificities ?

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# IC=12.550 IC/col=0.697 n_of_columns=18

specificity:

A |  11   0   0   0  11   8  11  24  24  24  24  72   2  87  96   0  24   0
C |   5   0   0   0   0  72   8  24  24  24  24   8   2   2   0  96  24  96
G |  11  96  96   0  16  11  13  24  24  24  24   8  90   2   0   0  24   0
T |  69   0   0  96  69   5  64  24  24  24  24   8   2   5   0   0  24   0

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updated Tue Jan 6 00:19:57 2026