5yx2_AD : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF DNMT3A-DNMT3L IN COMPLEX WITH DNA CONTAINING TWO CPG SITES
reference	Zhang et al. Nature 554 387 2018
source	HOMO SAPIENS
experiment	X-ray (resolution=2.65, R-factor=?)
structural superfamily	S-adenosyl-L-methionine-dependent methyltransferases;
reference complex	6w8b_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5yx2_A interface=88,89,90,91,207,209,210,211,256, aekrkpirvlslfdgiatgllvlkdlgiqvdryiasevcedsitvgmvrhqgkimyvgdvrsvtqkhiqewgpfdlviggspcndlsIVNParkglyegtgrlffefyrllhdarpkegddrpffwlfenvvamgvsdkrdisrflesnpvmidakevsaahraryfwgnlpgmnrplastvndklelqeclehgriakfskvrtiTtRSNsikqgkdqhfpvfmnekedilwctemervfgfpvhytdvsnmsrLarqrllgrswsvpvirhlfaplkeyfacv > 5yx2_D interface=88,89,90,91,207,208,209,210,211,256, aekrkpirvlslfdgiatgllvlkdlgiqvdryiasevcedsitvgmvrhqgkimyvgdvrsvtqkhiqewgpfdlviggspcndlsIVNParkglyegtgrlffefyrllhdarpkegddrpffwlfenvvamgvsdkrdisrflesnpvmidakevsaahraryfwgnlpgmnrplastvndklelqeclehgriakfskvrtiTTRSNsikqgkdqhfpvfmnekedilwctemervfgfpvhytdvsnmsrLarqrllgrswsvpvirhlfaplkeyfacv
interface signature	IVNPTRSNL/IVNPTTRSNL

Estimated binding specificities ?

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# IC=12.595 IC/col=0.700 n_of_columns=18

specificity:

A |   8   0   0   0  11  11  14  24  24  24  24  72   2  87  96   0  24   0
C |   5   0   0   0  11  66  11  24  24  24  24   8   2   5   0  96  24  96
G |   5  96  96   0   8   8   0  24  24  24  24   5  87   2   0   0  24   0
T |  78   0   0  96  66  11  71  24  24  24  24  11   5   2   0   0  24   0

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updated Wed Jul 30 14:35:12 2025