5yx2_AD : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF DNMT3A-DNMT3L IN COMPLEX WITH DNA CONTAINING TWO CPG SITES
reference	Zhang et al. Nature 554 387 2018
source	HOMO SAPIENS
experiment	X-ray (resolution=2.65, R-factor=?)
structural superfamily	S-adenosyl-L-methionine-dependent methyltransferases;
reference complex	6pa7_K
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5yx2_A interface=88,89,90,91,207,209,210,211,256, aekrkpirvlslfdgiatgllvlkdlgiqvdryiasevcedsitvgmvrhqgkimyvgdvrsvtqkhiqewgpfdlviggspcndlsIVNParkglyegtgrlffefyrllhdarpkegddrpffwlfenvvamgvsdkrdisrflesnpvmidakevsaahraryfwgnlpgmnrplastvndklelqeclehgriakfskvrtiTtRSNsikqgkdqhfpvfmnekedilwctemervfgfpvhytdvsnmsrLarqrllgrswsvpvirhlfaplkeyfacv > 5yx2_D interface=88,89,90,91,207,208,209,210,211,256, aekrkpirvlslfdgiatgllvlkdlgiqvdryiasevcedsitvgmvrhqgkimyvgdvrsvtqkhiqewgpfdlviggspcndlsIVNParkglyegtgrlffefyrllhdarpkegddrpffwlfenvvamgvsdkrdisrflesnpvmidakevsaahraryfwgnlpgmnrplastvndklelqeclehgriakfskvrtiTTRSNsikqgkdqhfpvfmnekedilwctemervfgfpvhytdvsnmsrLarqrllgrswsvpvirhlfaplkeyfacv
interface signature	IVNPTRSNL/IVNPTTRSNL

Estimated binding specificities ?

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# IC=12.546 IC/col=0.697 n_of_columns=18

specificity:

A |   0  24   0   0   2   2   7  24  24  24  24  67   7  68  96   0   0  70
C |   0  24   0   0   2  88   9  24  24  24  24   7   7  11   0  96  96  12
G |  96  24  96   0   2   4   7  24  24  24  24  12  72   7   0   0   0   7
T |   0  24   0  96  90   2  73  24  24  24  24  10  10  10   0   0   0   7

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updated Thu Jun 25 11:30:59 2026