interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURAL OF FOXC2 DNA BINDING DOMAIN BOUND TO PC PROMOTER
(FORKHEAD BOX PROTEIN C2)
referenceLiang et al. 'Nucleic 47 3752 2019
sourceHOMO SAPIENS
experimentX-ray (resolution=2.32, R-factor=0.220)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyFork head domain;
redundant complexes6lbm 6o3t 6ako
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRHS

Estimated binding specificities ?

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# IC=3.101 IC/col=0.620 n_of_columns=5 specificity:   
A |  54  24  54   0  96
C |  13  24  16  96   0
G |  16  24  13   0   0
T |  13  24  13   0   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  ------------------------------RGHT----ST--------------   L                           +-6akp_C    
                                                                              +--------3 
  ------------------------NAST--RGHT----STLT------------   L                  !        +-7cby_C    
                                                                      +-------7 
  ------------------------NAST--RGHT----STLT--------KA--   L          !       !      +---2c6y_A    
                                                                  +--11       +------4 
  --------------------QTNAST--RGHTNT--STLA--------------   L      !   !              +---2hdc_A    
                                                               +-13   !  
  ------------------------NAST--RGHTNT--STLT------------   L   !  !   +------------------7fj2_B    
                                                               !  !  
  ------------------SA------------------------------RG--       !  +----------------------2xcr_U    
                                                               !  
  --RC--------------------------------------------------       !                          +6l9z_S    
                                                               !                       +--2 
  --------RC--------------------------------------------       !                  +----5  +7cow_T    
                                                               !                  !    ! 
  ------------------------RG------YG--------------------     -15              +---6    +---1qbj_C    
                                                               !              !   ! 
  ------------------------NAST--RTHT----ST--------------   L   !     +--------9   +--------3co7_C    
                                                               !     !        ! 
  ------------------------RC------YG--------KT----------       !     !        !            +2acj_B    
                                                               !  +-12        +------------1 
  ----------------TTHT----KG----------------------------   L   !  !  !                     +7b0c_A    
                                                               !  !  !  
  ----------LTNTHG--RT--YTPT------------------------RT--   L   !  !  !         +-----------6qil_A    
                                                               +-14  +---------8 
  RT--------LT--NTHGTA----YTRG--------------------------   L      !            +-----------2efw_A    
                                                                  !  
  ----KAFA------------------------------------YANAKT--MC          !          +-------------3aaf_B    
                                                                  +---------10  
  ----------------PTPG--TTRG----------------------------   L                 +-------------5xxp_A    
                                                             

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updated Thu Sep 12 22:44:21 2024